PMID: 9174637Jan 1, 1997Paper

Cell cultures and associated retroviruses in multiple sclerosis. Collaborative Research Group on MS

Acta Neurologica Scandinavica. Supplementum
H PerronB Mandrand

Abstract

Retroviral particles associated with reverse transcriptase (RT) activity in cell-cultures from MS patients have been reported by different groups. Cell-cultures have been used for the study and characterization of the corresponding retroviral genome which we have shown is related to ERV9 in the pol region. Previously unpublished details of a study with monocyte cultures are presented together with observations on leptomeningeal and choroid-plexus cultures. The generation of self-transformed cultures after inhibition of interferon, followed by the loss of retroviral expression and recurrent apoptosis, is analyzed. Retroviral particles with RT-activity are produced in monocyte cultures with an apparent correlation with MS disease activity. However, though leptomeningeal and choroid plexus cells from MS can be passaged for a limited period, their evolution in vitro is not compatible with stable retroviral expression. These culture limitations greatly hampered progress on the elucidation of the retroviral genome sequence.

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Citations

Mar 30, 2012·Multiple Sclerosis : Clinical and Laboratory Research·Hervé PerronHans-Peter Hartung
Jan 29, 2016·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Tove Christensen
Mar 7, 2008·Microbiology and Molecular Biology Reviews : MMBR·Cécile VoissetDavid J Griffiths
Jun 25, 2002·AIDS Research and Human Retroviruses·Patric JernJonas Blomberg
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·H PerronB Mandrand
Apr 28, 2010·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Tove Christensen
Jan 1, 2006·Expert Review of Clinical Immunology·Antonina Dolei
Jul 31, 2007·Future Microbiology·Sunit Kumar Singh

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