Jul 1, 1996

Cell cycle analysis of proliferative zone chondrocytes in growth plates elongating at different rates

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
N J WilsmanM K Clayton


Regulation of postnatal growth of long bones occurs in multiple levels of chondrocytic activity, including stem cell proliferation, proliferative zone cycling, and regulation of changes in chondrocytic shape during hypertrophy. The differentiation sequence of chondrocytes is the same in all growth plates, but rates of elongation at a single point in time and over a period of time differ widely among individual growth plates, which suggests that the rates of sequential gene activation and suppression in this phenotypic pattern can vary. The purpose of this study was to investigate, directly and in vivo, parameters of the cell cycle of proliferative chondrocytes in growth plates growing at widely different rates at a single point in time in order to analyze the relationship between cell cycle time, including the duration of each phase of the cell cycle (G1, S, G2, and M), and the rate of growth. The experimental design used repeated pulse labeling with bromodeoxyuridine and was analyzed using a regression model of time of pulse label with increasing labeling index. Total cell cycle time was calculated as the inverse of the slope of the relationship of the labeling index and the time between labels. The y intercept was the calcula...Continue Reading

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Mentioned in this Paper

Developmental Growth Involved in Morphogenesis
Plasma Cell Labeling Index
Chondrocyte Proliferation
Bone Structure of Distal Tibia
August Rats
Entire Long Bone
Bone Structure of Distal Radius
Cell Differentiation Process

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