PMID: 6971443Dec 1, 1980Paper

Cell cycle and the differential expression of HLA-A,B and HLA-DR antigens on human B lymphoid cells

Proceedings of the National Academy of Sciences of the United States of America
S SarkarO W Jones

Abstract

Monoclonal antibodies specific to HLA antigens and the fluorescence-activated cell sorter were used to analyze the changes in the density of human histocompatibility antigens HLA-A,B and HLA-DR on the surface of synchronously growing WI-L2 cells (a human B cell line) progressing through the cell cycle. The WI-L2 cells were synchronized by density-dependent arrest in G1, and samples from G0, G1, late S and late G2 phases were used to determine the frequency distribution of cell volume, DNA content, and the relative amounts of cell surface HLA antigens; the observed density changes were calculated from these values. The HLA-A,B density remained nearly constant throughout the cell cycle, whereas the HLA-DR density increased sharply at the G2-M stage. These results suggest a cell cycle-dependent differential control of the expression of these two sets of histocompatibility antigens on B cells.

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Citations

May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M FellousM Revel
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·T Y BashamT C Merigan
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·R R HirschhornR Baserga
Sep 1, 1989·Journal of Neurosurgery·M ColombattiG Tridente
Jan 1, 1982·Leukemia Research·A Hirt, H P Wagner
Sep 15, 1982·Analytical Biochemistry·H S Kruth
Apr 1, 1981·Journal of Cellular Physiology·M C Glassy, C E Furlong
Jan 1, 1983·Cancer Immunology, Immunotherapy : CII·L M ZehngebotM Herlyn
Jan 1, 1986·Journal of Cancer Research and Clinical Oncology·M PetzschE Grundmann
Feb 15, 1984·International Journal of Cancer. Journal International Du Cancer·T LindmoA Sundan
Dec 20, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·W J MagnerT B Tomasi

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