Cell cycle arrest and induction of apoptosis by lycopene in LNCaP human prostate cancer cells

Journal of Medicinal Food
Eun-Sun Hwang, Phyllis E Bowen

Abstract

Lycopene is one of the major carotenoids and is found almost exclusively in tomatoes and tomato products. Since tomato consumption is associated with decreased risk of prostate cancer, characterizing the effects of lycopene on cell growth or survival, cell cycle progression, and apoptosis in LCNaP human prostate cancer cells might elucidate the mechanisms of actions of lycopene. To discover the possible anti-cancer mechanism of lycopene, water-soluble lycopene was used, and cell cycle arrest and apoptosis were measured. Placebo formulation at each lycopene dose at 0.1, 1, and 5 microM was used as a control. After 6, 24, and 48 hours of incubation, cells were harvested and measured for cell viability. Lycopene at 1 microM inhibited cell growth by 31%, compared with its placebo formulation after a 48-hour incubation. Lycopene at 5 microM increased the number of cells in the G(2)/M phase of the cell cycle from 13% to 28% and decreased S-phase cells from 45% to 29%, while no shifts in cell cycle were detected in placebo-treated groups. Apoptosis was observed at the 5 microM lycopene formulation at the late stages during the 24- and 48-hour treatments. Lycopene, therefore, deserves further study as a potential chemopreventive/chemot...Continue Reading

References

Jan 1, 1980·International Review of Cytology·A H WyllieA R Currie
Dec 6, 1995·Journal of the National Cancer Institute·E GiovannucciW C Willett
Nov 2, 2001·Toxicon : Official Journal of the International Society on Toxinology·Hans-Erick BeausoleilJ Daniel Dubreuil
Mar 7, 2002·Journal of the National Cancer Institute·Edward GiovannucciWalter C Willett
Oct 19, 2002·The Prostate·Alpana TyagiRajesh Agarwal
Sep 24, 2004·Journal of Medicinal Food·Eun-Sun Hwang, Phyllis E Bowen

❮ Previous
Next ❯

Citations

Aug 31, 2010·Cancer Metastasis Reviews·Hsueh-Li TanSteven K Clinton
Aug 8, 2012·Cancer Cell International·Anderson Junger TeodoroRadovan Borojevic
Jan 21, 2009·Der Urologe. Ausg. A·F G E PeraboP J Bastian
Nov 21, 2008·Nutrition Reviews·Jonathan R MeinXiang-Dong Wang
Mar 14, 2013·Cancer Prevention Research·Xi QiuRichard B van Breemen
Oct 30, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Erwan GourantonJean-François Landrier
Dec 15, 2007·Molecular Nutrition & Food Research·Maria Stacewicz-SapuntzakisPhyllis E Bowen
Oct 28, 2006·Archives of Biochemistry and Biophysics·Brian L LindshieldJohn W Erdman
Feb 16, 2010·Nutrition and Cancer·Karin Wertz
Sep 22, 2019·Nutrients·Tracey L LivingstoneMaria H Traka
Apr 15, 2006·The Journal of Nutrition·Jacqueline LimpensWytske M van Weerden
Jan 1, 2011·Cancers·Paola PalozzaMaria Cristina Mele
Mar 20, 2019·Food & Function·Monique de Barros EliasAnderson Junger Teodoro
Aug 20, 2020·Anais Da Academia Brasileira De Ciências·Mariana G CorreaAnderson J Teodoro
May 17, 2006·The Journal of Nutrition·Marija GajicJohn W Erdman
Sep 19, 2006·BJU International·Anuj GoyalAlan J Cooper
May 28, 2011·Free Radical Research·Mareike KelkelMarc Diederich
Mar 4, 2006·Experimental Biology and Medicine·Eun-Sun Hwang, Hyong Joo Lee
Sep 23, 2006·Expert Opinion on Investigational Drugs·Debra L BemisRalph Buttyan
Aug 2, 2018·Journal of Food Science and Technology·Poonam ChaudharyAvinash Kaur Nagpal
Sep 24, 2004·Journal of Medicinal Food·Eun-Sun Hwang, Phyllis E Bowen
Jan 19, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Emelia A AssarSassan Hafizi
Feb 1, 2006·Experimental Biology and Medicine·Keith R Martin
Nov 24, 2006·Molecular Cancer Therapeutics·Ang LiuRichard B van Breemen
Dec 8, 2020·Neurochemistry International·Padmanabh SinghM K Thakur
Jul 28, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wang Jia QiTang Ze Yao
Jan 21, 2012·Journal of Agricultural and Food Chemistry·Chih-Min YangMiao-Lin Hu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis