Cell cycle arrest associated with anoxia-induced quiescence, anoxic preconditioning, and embryonic diapause in embryos of the annual killifish Austrofundulus limnaeus.

Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
Camie L MellerJ E Podrabsky

Abstract

Embryos of the annual killifish Austrofundulus limnaeus can enter into dormancy associated with diapause and anoxia-induced quiescence. Dormant embryos are composed primarily of cells arrested in the G(1)/G(0) phase of the cell cycle based on flow cytometry analysis of DNA content. In fact, most cells in developing embryos contain only a diploid complement of DNA, with very few cells found in the S, G(2), or M phases of the cell cycle. Diapause II embryos appear to be in a G(0)-like state with low levels of cyclin D1 and p53. However, the active form of pAKT is high during diapause II. Exposure to anoxia causes an increase in cyclin D1 and p53 expression in diapause II embryos, suggesting a possible re-entry into the cell cycle. Post-diapause II embryos exposed to anoxia or anoxic preconditioning have stable levels of cyclin D1 and stable or reduced levels of p53. The amount of pAKT is severely reduced in 12 dpd embryos exposed to anoxia or anoxic preconditioning. This study is the first to evaluate cell cycle control in embryos of A. limnaeus during embryonic diapause and in response to anoxia and builds a foundation for future research on the role of cell cycle arrest in supporting vertebrate dormancy.

References

Apr 1, 1972·Journal of Reproduction and Fertility·M I Sherman, P W Barlow
Dec 27, 1995·Biochimica Et Biophysica Acta·A YardenB Geiger
Aug 8, 1997·Biochimica Et Biophysica Acta·N Almog, V Rotter
Mar 5, 1999·Cellular and Molecular Life Sciences : CMLS·J Choi, L A Donehower
Jul 17, 1999·Brain Research. Molecular Brain Research·G TomasevicT Wieloch
Dec 21, 2000·Physiological and Biochemical Zoology : PBZ·J E Podrabsky, S C Hand
Dec 22, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J E PodrabskyS C Hand
Jun 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·P A Padilla, M B Roth
Dec 1, 2001·Annual Review of Entomology·David L Denlinger
Jun 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Narci TeohGeoffrey Farrell
Dec 4, 2003·FEBS Letters·Mihaela M Mocanu, Derek M Yellon
Jun 6, 2007·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Linda Fergusson-Kolmes, Jason E Podrabsky
Jun 19, 2007·The Journal of Experimental Biology·Jason E PodrabskyGeorge N Somero
Jun 22, 2007·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Ben E Machado, Jason E Podrabsky
May 29, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Sarah L MiltonHoward M Prentice
Oct 17, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kåre-Olav StensløkkenJarle Vaage
Sep 18, 2009·Nature Reviews. Cancer·Karen H Vousden, Kevin M Ryan
May 18, 2010·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Jeffrey M Duerr, Jason E Podrabsky
Jul 14, 2010·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·T Chennault, J E Podrabsky
May 31, 2011·Cellular Signalling·Ingeborg HersJeremy M Tavaré

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Citations

Dec 18, 2013·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Camie L MellerJason E Podrabsky
Aug 11, 2016·Integrative and Comparative Biology·Jason E Podrabsky, Natalie E Wilson
Aug 21, 2016·Biochimica Et Biophysica Acta·Emily ChenChristos Chinopoulos
Apr 14, 2017·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Karen L M Martin, Jason E Podrabsky
Nov 13, 2014·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Josiah T Wagner, Jason E Podrabsky
Jun 5, 2019·The Journal of Experimental Biology·Josiah T WagnerJason E Podrabsky
Apr 8, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Steven C HandRichard Roy
Feb 10, 2017·Physiological Reviews·Kenneth B Storey, Janet M Storey
Dec 14, 2018·International Journal of Molecular Sciences·Sreeja SarasammaChung-Der Hsiao
Aug 30, 2020·The Journal of Experimental Biology·Daniel E Zajic, Jason E Podrabsky
Jun 19, 2015·The Journal of Experimental Biology·Jason E Podrabsky, Steven C Hand
Aug 12, 2020·The Journal of Experimental Biology·Daniel E ZajicJason E Podrabsky

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