PMID: 9552354Jan 1, 1995Paper

Cell cycle control of DNA replication

Progress in Cell Cycle Research
R Fotedar, A Fotedar

Abstract

The cell cycle is driven by the sequential activation of a family of cyclin-dependent kinases (cdk), which phosphorylate and activate proteins that execute events critical to cell cycle progression. In mammalian cells cdk2-cyclin A has a role in S phase. Many replication proteins are potential substrates for this cdk kinase, suggesting that initiation, elongation and checkpoint control of replication could all be regulated by cdk2. The association of PCNA, a replication protein, with cdk-cyclins during G-1 to S phase transition and with cdk-cyclin inhibitors, adds an interesting complexity to regulation of DNA replication.

Citations

Sep 25, 2003·Journal of Cellular Biochemistry·Johannes Boonstra
Jul 7, 2016·Nucleic Acids Research·Giancarlo BaroneSpencer J Collis
Apr 10, 1999·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·I Salles-PassadorR Fotedar
Oct 4, 2005·Advances in Enzyme Regulation·Angélique van OpstalJohannes Boonstra
Aug 31, 2010·Molecular and Cellular Neurosciences·Beatriz Valle-ArgosManuel Nieto-Sampedro

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