Abstract
The cell cycle is driven by the sequential activation of a family of cyclin-dependent kinases (cdk), which phosphorylate and activate proteins that execute events critical to cell cycle progression. In mammalian cells cdk2-cyclin A has a role in S phase. Many replication proteins are potential substrates for this cdk kinase, suggesting that initiation, elongation and checkpoint control of replication could all be regulated by cdk2. The association of PCNA, a replication protein, with cdk-cyclins during G-1 to S phase transition and with cdk-cyclin inhibitors, adds an interesting complexity to regulation of DNA replication.
Citations
May 22, 2001·Molecular and Cellular Biology·Z Sever-ChroneosE S Knudsen
Jun 26, 2002·Carcinogenesis·Dev KaranSurinder K Batra
Aug 23, 2002·Molecular and Cellular Biology·Tetsuo MaruyamaKeiko Ozato
Sep 25, 2003·Journal of Cellular Biochemistry·Johannes Boonstra
Aug 16, 2005·FEBS Letters·Yi WenJames W Simpkins
Apr 1, 1997·Chromosoma·D CannellaR Fotedar
May 4, 1999·Memórias do Instituto Oswaldo Cruz·S C WelburnN B Murphy
Jul 7, 2016·Nucleic Acids Research·Giancarlo BaroneSpencer J Collis
Jul 11, 2003·Oncogene·Ghislaine HennekeUlrich Hübscher
Jun 28, 2000·Experimental Eye Research·A H SchönthalM D Trousdale
Apr 10, 1999·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·I Salles-PassadorR Fotedar
Jul 29, 2004·DNA Repair·Sara K BinzMarc S Wold
Jul 28, 2004·Gene·Johannes Boonstra, Jan Andries Post
Oct 4, 2005·Advances in Enzyme Regulation·Angélique van OpstalJohannes Boonstra
May 11, 2007·Experimental Cell Research·Randall A PhelpsDavid M Hockenbery
Aug 31, 2010·Molecular and Cellular Neurosciences·Beatriz Valle-ArgosManuel Nieto-Sampedro