Cell cycle control related proteins (p53, p21, and Rb) and transforming growth factor beta (TGFbeta) in benign and carcinomatous (in situ and infiltrating) human breast: implications in malignant transformations

Cancer Investigation
Ignacio García-Tuñón Royuela

Abstract

A comparative study of the products of the cell cycle control genes p53 (mutated form), p21, Rb (nonphosphorylated and phosphorylated form) and TGFbeta was performed by immunohistochemistry and Western blot, in benign breast disorders and breast cancer (in situ and infiltrating tumors). For the five proteins studied, the relative numbers of positively stained cells were higher in in situ carcinoma than in benign breast diseases. In infiltrating breast tumors, the relative numbers of positively stained cells were even higher than in in situ tumors except for the percentage of pRb immunostained cells, which decreased slightly in infiltrative tumors. For the other four proteins, the percentages of positively stained cases were similar to those found in in situ tumors. In the three groups of patients, TGFbeta immunoreaction appeared in the cytoplasm while immunoreactions to p53, p21, Rb, and pRb were found always in the nucleus except for p21 in in situ tumors, which showed cytoplasmic immunoreaction. Present results suggest that accumulation of mutated p53, cytoplasmic p21, and pRb in breast gland epithelium might be a crucial point in the development of in situ adenocarcinoma. In the infiltrating tumors, the expression of p21 in ...Continue Reading

References

Jul 1, 1991·Japanese Journal of Cancer Research : Gann·K IwayaS Hirohashi
Jul 1, 1995·The Journal of Pathology·F C SchmittC Lopes
Nov 18, 1994·Cell·C J Sherr
Apr 22, 1996·International Journal of Cancer. Journal International Du Cancer·R SeshadriD J Horsfall
Apr 1, 1997·Breast Cancer Research and Treatment·S G DiabR M Elledge
Mar 12, 1998·International Journal of Cancer. Journal International Du Cancer·E A DublinD M Barnes
Jul 31, 1998·Acta Cytologica·A Ioakim-LiossiG Vaiopoulos
Sep 10, 1998·Journal of the National Cancer Institute·T E RohanR A Kandel
Jan 7, 2000·The American Journal of Pathology·J F Simpson, D L Page
Jan 7, 2000·The American Journal of Pathology·J LukasM F Press
Feb 15, 2001·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·S C HeffelfingerE E Lower
Nov 27, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Z E WintersC J Norbury
Aug 28, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Thomas C PuttiIan O Ellis

❮ Previous
Next ❯

Citations

Mar 28, 2008·Proceedings of the National Academy of Sciences of the United States of America·Shuying LiuGordon B Mills
Aug 20, 2008·Human Gene Therapy·M Bazan-PeregrinoL W Seymour
Aug 19, 2007·BMC Cancer·Ignacio García-TuñónMar Royuela
Aug 7, 2012·Chemical & Pharmaceutical Bulletin·Pattama WongsirisinPornngarm Limtrakul
Mar 26, 2010·Breast Cancer Research and Treatment·Ozcan MetInge Marie Svane
May 22, 2007·American Journal of Clinical Pathology·L Jeffrey Medeiros, Kojo S J Elenitoba-Johnson
Sep 13, 2008·Expert Review of Molecular Diagnostics·Philip D Hardt, Nils Ewald

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.