PMID: 6984438Dec 1, 1982Paper

Cell cycle dependence of mitotic delay in X-irradiated normal and ataxia-telangiectasia fibroblasts

International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
D Scott, F Zampetti-Bosseler

Abstract

The delay in progression of X-irradiated cells through the cell cycle, which is more pronounced in normal (N) than in A-T fibroblasts, is greatest for cells in G2 at the time of irradiation. The greater effect of radiation on the initiation of DNA synthesis in N than in A-T cells is reflected in the shape of the percent labelled mitosis curves after 3H-thymidine treatment. The duration of the S phase in unirradiated A-T cells is greater than in N cells. Any explanation of the underlying defect in A-T must account not only for the reduced radiosensitivity of DNA synthesis but for the lesser delay in G2. Our data support the hypothesis that DNA is the principal target for radiation-induced G2 delay.

References

Jul 1, 1977·Journal of Molecular Biology·L F Povirk
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J P Murnane, R B Painter
Jan 1, 1980·Cytogenetics and Cell Genetics·M M Cohen, S J Simpson

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Citations

Jan 1, 1997·Annual Review of Immunology·M F Lavin, Y Shiloh
Dec 16, 2006·Radiation Protection Dosimetry·G I Terzoudi, G E Pantelias
Jul 31, 1998·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M F Lavin
Aug 5, 2000·Free Radical Biology & Medicine·R E ShackelfordR S Paules
Mar 6, 2008·American Journal of Human Genetics·Avanti Kulkarni, David M Wilson

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