Cell cycle-dependent regulation of extra-adrenal glucocorticoid synthesis in murine intestinal epithelial cells

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Atanas AtanasovThomas Brunner

Abstract

Glucocorticoids are anti-inflammatory steroids with important applications in the treatment of inflammatory diseases. Endogenous glucocorticoids are mainly produced by the adrenal glands, although there is increasing evidence for extra-adrenal sources. Recent findings show that intestinal crypt cells produce glucocorticoids, which contribute to the maintenance of intestinal immune homeostasis. Intestinal glucocorticoid synthesis is critically regulated by the transcription factor liver receptor homologue-1 (LRH-1). As expression of steroidogenic enzymes and LRH-1 is restricted to the proliferating cells of the crypts, we aimed to investigate the role of the cell cycle in the regulation of LRH-1 activity and intestinal glucocorticoid synthesis. We here show that either pharmacological or molecular modulation of cell cycle progression significantly inhibited expression of steroidogenic enzymes and synthesis of glucocorticoids in intestinal epithelial cells. Synchronization of intestinal epithelial cells in the cell cycle revealed that expression of steroidogenic enzymes is preferentially induced at the G(1)/S stage. Differentiation of immature intestinal epithelial cells to mature nonproliferating cells also resulted in reduced e...Continue Reading

References

Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R H WhiteheadP S Jat
Dec 24, 1993·Science·S van den Heuvel, E Harlow
May 1, 1993·The Journal of Experimental Medicine·J A GonzaloG Kroemer
Jun 1, 1996·The American Journal of Physiology·M BensA Vandewalle
Apr 11, 1997·The Journal of Biological Chemistry·X TanJ Y Wang
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·K HelinP Norgaard
May 23, 2002·Recent Progress in Hormone Research·Keith L ParkerBernard P Schimmer
Sep 12, 2003·The Journal of Endocrinology·R J Farrell, D Kelleher
Jun 25, 2004·The Journal of Biological Chemistry·Ralph TorglerThomas Brunner
Aug 26, 2004·Molecular Cell·Oronza A BotrugnoKristina Schoonjans
Dec 15, 2004·The Journal of Experimental Medicine·Igor CimaThomas Brunner
Feb 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Kristina SchoonjansJohan Auwerx
Mar 16, 2005·The Journal of Biological Chemistry·Eric BatschéJacques Drouin
Apr 9, 2005·Endocrine Reviews·Ray-Chang WuBert W O'Malley
Jan 28, 2006·The Journal of Biological Chemistry·Yoon-Kwang LeeDavid D Moore
Aug 23, 2006·The Journal of Experimental Medicine·Matthias MuellerThomas Brunner
Aug 29, 2006·Oncogene·C Giacinti, A Giordano
Oct 28, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Michel A BoivinThomas Y Ma
Aug 3, 2007·Proceedings of the National Academy of Sciences of the United States of America·Agnes CosteKristina Schoonjans

❮ Previous
Next ❯

Citations

May 28, 2013·Molecular and Cellular Endocrinology·Gergely TalabérSam Okret
Jan 25, 2011·Oncogene·D SidlerT Brunner
May 5, 2010·The Journal of Experimental Medicine·Mario NotiThomas Brunner
May 8, 2013·The Journal of Experimental Medicine·Indrajit DasMichael A McGuckin
May 5, 2011·American Journal of Physiology. Endocrinology and Metabolism·Matthew D TavesKiran K Soma
Sep 19, 2009·Molecular Endocrinology·Jinhan HeWen Xie
Mar 15, 2013·Bone·Li ZhengPetros Papagerakis
Jun 6, 2009·Seminars in Immunopathology·Mario NotiThomas Brunner
Jul 22, 2014·Annals of Medicine·Feodora KostadinovaThomas Brunner
Jan 7, 2015·Steroids·Guillaume BouguenBenjamin Bertin
Feb 22, 2012·European Journal of Oral Sciences·Maria Athanassiou-PapaefthymiouPetros Papagerakis
Jan 5, 2011·Biochimica Et Biophysica Acta·Pablo J Fernandez-MarcosKristina Schoonjans
Jan 29, 2019·Genes and Immunity·M Eugenia Delgado, Thomas Brunner
Jul 23, 2019·Science Advances·Carina SeitzThomas Brunner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.