PMID: 9557655Apr 29, 1998Paper

Cell cycle dysregulation by human cytomegalovirus: influence of the cell cycle phase at the time of infection and effects on cyclin transcription

Journal of Virology
B S SalvantD H Spector

Abstract

Human cytomegalovirus (HCMV) infection inhibits cell cycle progression and alters the expression of cyclins E, A, and B (F. M. Jault, J.-M. Jault, F. Ruchti, E. A. Fortunato, C. Clark, J. Corbeil, D. D. Richman, and D. H. Spector, J. Virol. 69:6697-6704, 1995). In this study, we examined cell cycle progression, cyclin gene expression, and early viral events when the infection was initiated at different points in the cell cycle (G0, G1, and S). In all cases, infection led to cell cycle arrest. Cells infected in G0 or G1 phase also showed a complete or partial absence, respectively, of cellular DNA synthesis at a time when DNA synthesis occurred in the corresponding mock-infected cells. In contrast, when cells were infected near or during S phase, many cells were able to pass through S phase and undergo mitosis prior to cell cycle arrest. S-phase infection also produced a delay in the appearance of the viral cytopathic effect and in the synthesis of immediate-early and early proteins. Labeling of cells with bromodeoxyuridine immediately prior to HCMV infection in S phase revealed that viral protein expression occurred primarily in cells which were not engaged in DNA synthesis at the time of infection. The viral-mediated induction...Continue Reading

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Citations

Feb 22, 2001·The Journal of Experimental Medicine·R M PrestiH W Virgin
Jan 8, 2003·Reviews in Medical Virology·Elizabeth A Fortunato, Deborah H Spector
Jul 14, 2010·Bioscience, Biotechnology, and Biochemistry·Zhiqiang BaiXuxia Song
Feb 26, 2013·In Vitro Cellular & Developmental Biology. Animal·Siti-Nazrina CamalxamanMohd Lila Mohd-Azmi
Mar 20, 2013·Acta Biochimica Et Biophysica Sinica·Kezhen WangTianhong Zhou
Mar 17, 2015·Medical Microbiology and Immunology·Emma Poole, John Sinclair
Apr 15, 2015·Antimicrobial Agents and Chemotherapy·Sujayita RoyRavit Arav-Boger
Jan 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·E A FortunatoD H Spector
Jan 14, 2004·The Journal of General Virology·Lüder WiebuschChristian Hagemeier
Nov 5, 2002·Journal of Virology·Emanuela NorisSanto Landolfo
Nov 8, 2005·Journal of Neuroscience Research·Maxim C-J CheeranJames R Lokensgard
Feb 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yoon-Jae Song, Mark F Stinski
Aug 17, 2006·Journal of Virology·N C CasavantE A Fortunato
Aug 7, 2007·Reviews in Medical Virology·Mark Bain, John Sinclair
Mar 30, 2011·Cell Research·Sung-Bau LeeLi-Jung Juan

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