Cell cycle independent role of Cyclin E during neural cell fate specification in Drosophila is mediated by its regulation of Prospero function

Developmental Biology
Christian BergerGerhard M Technau

Abstract

During development, neural progenitor cells or neuroblasts generate a great intra- and inter-segmental diversity of neuronal and glial cell types in the nervous system. In thoracic segments of the embryonic central nervous system of Drosophila, the neuroblast NB6-4t undergoes an asymmetric first division to generate a neuronal and a glial sublineage, while abdominal NB6-4a divides once symmetrically to generate only 2 glial cells. We had earlier reported a critical function for the G1 cyclin, CyclinE (CycE) in regulating asymmetric cell division in NB6-4t. Here we show that (i) this function of CycE is independent of its role in cell cycle regulation and (ii) the two functions are mediated by distinct domains at the protein level. Results presented here also suggest that CycE inhibits the function of Prospero and facilitates its cortical localization, which is critical for inducing stem cell behaviour, i.e. asymmetric cell division of NB6-4t. Furthermore our data imply that CycE is required for the maintenance of stem cell identity of most other neuroblasts.

References

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Citations

Apr 18, 2014·Development, Growth & Differentiation·Leo Tsuda, Young-Mi Lim
Apr 2, 2016·Nature Reviews. Molecular Cell Biology·Per HydbringPiotr Sicinski
May 31, 2012·The Biochemical Journal·Christopher Hindley, Anna Philpott
Mar 29, 2014·Cell Cycle·Takao IshidateMasaki Shirayama
Jan 11, 2014·Fly·Alicia Estacio-Gómez, Fernando J Díaz-Benjumea
May 29, 2012·Fly·Hakima Flici, Angela Giangrande
Nov 10, 2016·PLoS Genetics·Junko OdajimaPiotr Sicinski
Jul 10, 2020·The Journal of Cell Biology·Yu-Yang JiangJacek Gaertig
Oct 24, 2018·Journal of Developmental Biology·Katherine Harding, Kristin White
Sep 21, 2019·Apoptosis : an International Journal on Programmed Cell Death·Mianli BianShizhong Zheng
Nov 18, 2020·Proceedings of the National Academy of Sciences of the United States of America·Antonio de la TorreJosé Pérez-Martín
May 31, 2021·Trends in Cell Biology·Chen ChuPiotr Sicinski
Oct 22, 2011·Developmental Cell·Aurnab Ghose, L S Shashidhara

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