Cell Cycle Machinery in Bacillus subtilis

Sub-cellular Biochemistry
Jeff Errington, Ling Juan Wu

Abstract

Bacillus subtilis is the best described member of the Gram positive bacteria. It is a typical rod shaped bacterium and grows by elongation in its long axis, before dividing at mid cell to generate two similar daughter cells. B. subtilis is a particularly interesting model for cell cycle studies because it also carries out a modified, asymmetrical division during endospore formation, which can be simply induced by starvation. Cell growth occurs strictly by elongation of the rod, which maintains a constant diameter at all growth rates. This process involves expansion of the cell wall, requiring intercalation of new peptidoglycan and teichoic acid material, as well as controlled hydrolysis of existing wall material. Actin-like MreB proteins are the key spatial regulators that orchestrate the plethora of enzymes needed for cell elongation, many of which are thought to assemble into functional complexes called elongasomes. Cell division requires a switch in the orientation of cell wall synthesis and is organised by a tubulin-like protein FtsZ. FtsZ forms a ring-like structure at the site of impending division, which is specified by a range of mainly negative regulators. There it recruits a set of dedicated division proteins to form ...Continue Reading

Citations

Mar 12, 2019·Future Microbiology·Imrich BarákNaďa Labajová
Feb 7, 2018·Frontiers in Microbiology·Katarína MuchováImrich Barák
Aug 14, 2019·Journal of Bacteriology·Lauren R HammondPrahathees J Eswara
Jul 15, 2020·Annual Review of Microbiology·Kanika KhannaKit Pogliano
May 20, 2020·Nature Reviews. Microbiology·Alexander J F EganWaldemar Vollmer
Aug 20, 2020·Nature Communications·Ling Juan WuJeff Errington
Apr 15, 2021·MBio·Helge FeddersenMarc Bramkamp
Jun 10, 2021·Nature Communications·Phillip NußbaumSonja-Verena Albers
Jul 13, 2021·Frontiers in Microbiology·Anne GalinierFrédérique Pompeo
Aug 10, 2021·Frontiers in Cellular and Infection Microbiology·Ann L PowerJohn Love
Aug 20, 2021·Molecular Microbiology·Jordan DelisleThierry Doan

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Methods Mentioned

BETA
electron cryotomography
2-hybrid
pull downs
GTase
glycerophosphotransferase
pull-down
electron microscopy
fluorescence imaging
fluorescence recovery after photobleaching

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