PMID: 374612Jan 1, 1979Paper

Cell-cycle phase-dependence of drug-induced cycle progression delay

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
W GöhdeB Barlogie

Abstract

The effect of adriamycin on cell cycle phase progression of CHO cells synchronized into the various phases of the cell cycle by elutriation was investigated by high resolution pulse cytophotometry. Cells treated in all phases of the cell cycle showed delay in their subsequent progression. In addition to the wellknown block of cells in the G2-phase, a delay in passage of cells from G1 to S and a decreased rate of transit through the S-phase were observed. A broadening of the DNA distributions of the treated cells was observed after cell division indicating induction of chromosomal abnormalities.

Citations

Jan 1, 1984·Pharmacology & Therapeutics·S C Barranco
Mar 22, 2002·The Lancet Oncology·A J Davis, J F Tannock
Sep 1, 1980·Cell Biophysics·P C KengK T Wheeler
Feb 1, 1985·European Journal of Cancer & Clinical Oncology·N Tokita, M R Raju
Jan 1, 1981·Acta Radiologica. Oncology·U HackerK Müller

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