PMID: 3768934Jul 1, 1986Paper

Cell cycle phase sensitivity to cis-dichloro-bis (isopropylamine) trans-dihydroxy platinum (IV) (CHIP)

Cell and Tissue Kinetics
P G Edwards, A H Nias

Abstract

Cis-dichloro-bis (isopropylamine) trans-dihydroxy platinum (IV) (CHIP) is a second generation platinum coordination complex now in Phase II clinical trials. In vitro studies with Chinese Hamster Ovary cell cultures show that CHIP is a phase-sensitive drug, being most cytotoxic to cells in early G1 phase and least toxic to late S and G2 phase cells. The dose-modifying factor between the drug sensitivity of cells treated in G1 and in late S phase is 1.6. These findings and their clinical significance are discussed with respect to the phase sensitivity of other cytotoxic agents.

References

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Apr 1, 1963·Experimental Cell Research·T TERASIMA, L J TOLMACH

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Citations

Jul 1, 1996·Human & Experimental Toxicology·N A BoughattasF Lévi

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