Cell-cycle phospho-regulation of the kinetochore.

Current Genetics
Cinzia KlemmGuðjón Ólafsson

Abstract

The kinetochore is a mega-dalton protein assembly that forms within centromeric regions of chromosomes and directs their segregation during cell division. Here we review cell cycle-mediated phosphorylation events at the kinetochore, with a focus on the budding yeast Saccharomyces cerevisiae and the insight gained from forced associations of kinases and phosphatases. The point centromeres found in the budding yeast S. cerevisiae are one of the simplest such structures found in eukaryotes. The S. cerevisiae kinetochore comprises a single nucleosome, containing a centromere-specific H3 variant Cse4CENP-A, bound to a set of kinetochore proteins that connect to a single microtubule. Despite the simplicity of the budding yeast kinetochore, the proteins are mostly homologous with their mammalian counterparts. In some cases, human proteins can complement their yeast orthologs. Like its mammalian equivalent, the regulation of the budding yeast kinetochore is complex: integrating signals from the cell cycle, checkpoints, error correction, and stress pathways. The regulatory signals from these diverse pathways are integrated at the kinetochore by post-translational modifications, notably phosphorylation and dephosphorylation, to control c...Continue Reading

References

May 23, 1996·Molecular & General Genetics : MGG·W Jiang, Y Koltin
Dec 1, 1996·Molecular and Cellular Biology·C F Hardy, A Pautz
Oct 5, 2001·Nature Reviews. Molecular Cell Biology·P Cohen, S Frame
Jun 14, 2002·Trends in Cell Biology·Khalil AhmedClaude Cochet
Apr 8, 2003·Journal of Cell Science·Jonathan P AumaisLi-Yuan Yu-Lee
Jul 11, 2003·Developmental Cell·Tianhua ZhouRaymond L Erikson
Jul 11, 2003·The EMBO Journal·Christopher H GrayDavid Barford
Oct 11, 2003·Molecular Biology of the Cell·Rosella VisintinAngelika Amon
Oct 17, 2003·Nature·Won-Ki HuhErin K O'Shea
Oct 24, 2003·Nature·Jeffrey A UbersaxDavid O Morgan
Nov 8, 2003·Science·Gislene Pereira, Elmar Schiebel
Jun 3, 2004·Nature Reviews. Molecular Cell Biology·Francis A BarrErich A Nigg
Oct 29, 2004·Molecular and Cellular Biology·Jung-Eun ParkKyung S Lee
Jan 22, 2005·Current Opinion in Cell Biology·Anna Akhmanova, Casper C Hoogenraad
Mar 25, 2005·Nature Methods·Sam A Johnson, Tony Hunter
Dec 2, 2005·The Journal of Biological Chemistry·Guillaume ValentinFlavio Della Seta
Dec 27, 2005·Nature Cell Biology·Hidemasa GotoMasaki Inagaki
Feb 4, 2006·Journal of Biomedical Science·Li MaXueliang Zhu
Jul 25, 2006·Current Biology : CB·Michiya NishinoLi-Yuan Yu-Lee
Oct 25, 2006·Nature Methods·Ulrich RothbauerHeinrich Leonhardt
Dec 19, 2006·Nature Cell Biology·Erika L Woodbury, David O Morgan
Mar 23, 2007·The Journal of Biological Chemistry·Shigeru MatsumuraEisuke Nishida
Apr 12, 2007·Nature Reviews. Molecular Cell Biology·Andrea Musacchio, Edward D Salmon
May 18, 2007·Molecular Biology of the Cell·Lina MaVivien Measday
Jun 15, 2007·The Journal of Cell Biology·Anton KhmelinskiiElmar Schiebel
Oct 24, 2007·Molecular & Cellular Proteomics : MCP·Ulrich RothbauerHeinrich Leonhardt
Nov 21, 2007·Chemistry & Biology·Jennifer L SneadKevan M Shokat
Dec 15, 2007·Genes & Development·Etsushi KitamuraTomoyuki U Tanaka
Feb 1, 2008·Cell Cycle·Anton Khmelinskii, Elmar Schiebel
Apr 16, 2008·Journal of Cell Science·Fabrice CaudronCécile Boscheron
May 15, 2008·Developmental Cell·Mark PetronczkiJan-Michael Peters

❮ Previous
Next ❯

Citations

Aug 20, 2021·Frontiers in Molecular Biosciences·Irene Delgado-Román, Mari Cruz Muñoz-Centeno
Aug 26, 2021·Molecular Biology of the Cell·Prashant K MishraMunira A Basrai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.