Cell-cycle progress in obligate predatory bacteria is dependent upon sequential sensing of prey recognition and prey quality cues

Proceedings of the National Academy of Sciences of the United States of America
Or RotemEdouard Jurkevitch

Abstract

Predators feed on prey to acquire the nutrients necessary to sustain their survival, growth, and replication. In Bdellovibrio bacteriovorus, an obligate predator of Gram-negative bacteria, cell growth and replication are tied to a shift from a motile, free-living phase of search and attack to a sessile, intracellular phase of growth and replication during which a single prey cell is consumed. Engagement and sustenance of growth are achieved through the sensing of two unidentified prey-derived cues. We developed a novel ex vivo cultivation system for B. bacteriovorus composed of prey ghost cells that are recognized and invaded by the predator. By manipulating their content, we demonstrated that an early cue is located in the prey envelope and a late cue is found within the prey soluble fraction. These spatially and temporally separated cues elicit discrete and combinatory regulatory effects on gene transcription. Together, they delimit a poorly characterized transitory phase between the attack phase and the growth phase, during which the bdelloplast (the invaded prey cell) is constructed. This transitory phase constitutes a checkpoint in which the late cue presumably acts as a determinant of the prey's nutritional value before t...Continue Reading

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Citations

Jan 1, 2015·Microorganisms·Riccardo RussoNancy D Connell
Dec 15, 2015·Environmental Microbiology·Juana PérezJosé Muñoz-Dorado
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Jan 13, 2019·Applied and Environmental Microbiology·Benoit PaixStéphan Jacquet
May 12, 2019·Applied and Environmental Microbiology·Łukasz MakowskiJolanta Zakrzewska-Czerwińska
Jan 19, 2020·Applied and Environmental Microbiology·Daniel YoudkesEdouard Jurkevitch
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Sep 5, 2020·The ISME Journal·Rajesh SathyamoorthyEdouard Jurkevitch

Related Concepts

Metazoa
Cell Cycle
Predatory Behavior
Bacterial Physiological Phenomena
Cell Cycle
Cell Growth
Gram-Negative Bacteria
Transcription, Genetic
Virus Replication
Intracellular

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