Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis

Open Biology
Miguel Sanchez-AlvarezChris Bakal

Abstract

We show that phospholipid anabolism does not occur uniformly during the metazoan cell cycle. Transition to S-phase is required for optimal mobilization of lipid precursors, synthesis of specific phospholipid species and endoplasmic reticulum (ER) homeostasis. Average changes observed in whole-cell phospholipid composition, and total ER lipid content, upon stimulation of cell growth can be explained by the cell cycle distribution of the population. TORC1 promotes phospholipid anabolism by slowing S/G2 progression. The cell cycle stage-specific nature of lipid biogenesis is dependent on p53. We propose that coupling lipid metabolism to cell cycle progression is a means by which cells have evolved to coordinate proliferation with cell and organelle growth.

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Citations

Nov 7, 2016·Current Opinion in Biotechnology·An NguyenMichael Jo Wakelam
Jun 28, 2018·Journal of Lipid Research·An NguyenMichael J O Wakelam
Nov 7, 2019·Molecular Biology of the Cell·Samar SayedyahosseinDavid B Sacks
Nov 12, 2016·Journal of Neuro-oncology·Shunsuke NakaeYuichi Hirose
May 28, 2019·Plant Signaling & Behavior·Nelson LaurentPatricia Gerbeau-Pissot
Apr 15, 2020·Nature Biotechnology·Junyue CaoJay Shendure
Jan 6, 2021·Molecular Microbiology·Michael W Panas, John C Boothroyd

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Methods Mentioned

BETA
RNA array
flow cytometry
fluorescence-activated cell sorting
glycosylation
transfection
PCR
FACS

Software Mentioned

Acapella
FlowJo cytometry package
raph P ad P rism

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