Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication.

Proceedings of the National Academy of Sciences of the United States of America
Julien MouyssetThorsten Hoppe

Abstract

Since cdc48 mutants were isolated by the first genetic screens for cell division cycle (cdc) mutants in yeast, the requirement of the chaperone-like ATPase Cdc48/p97 during cell division has remained unclear. Here, we discover an unanticipated function for Caenorhabditis elegans CDC-48 in DNA replication linked to cell cycle control. Our analysis of the CDC-48(UFD-1/NPL-4) complex identified a general role in S phase progression of mitotic cells essential for embryonic cell division and germline development of adult worms. These developmental defects result from activation of the DNA replication checkpoint caused by replication stress. Similar to loss of replication licensing factors, DNA content is strongly reduced in worms depleted for CDC-48, UFD-1, and NPL-4. In addition, these worms show decreased DNA synthesis and hypersensitivity toward replication blocking agents. Our findings identified a role for CDC-48(UFD-1/NPL-4) in DNA replication, which is important for cell cycle progression and genome stability.

References

Mar 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·T HaafD C Ward
Jul 3, 1997·Nature·H KondoG Warren
Nov 6, 1998·Nature·L Timmons, A Fire
Jun 13, 2001·The Journal of Cell Biology·K OegemaA A Hyman
Sep 7, 2001·Genes & Development·R T Abraham
Aug 21, 2002·The Journal of Cell Biology·Fumihiko UranoDavid Ron
Dec 10, 2002·Science·Jason Pellettieri, Geraldine Seydoux
Aug 26, 2003·Molecular Biology of the Cell·Juneth Joaquin PartridgeFred Eliezer Indig
Aug 28, 2003·Médecine sciences : M/S·Christelle Gally, Jean-Louis Bessereau
Mar 24, 2004·Journal of Structural Biology·Fred Eliezer IndigVilhelm A Bohr
Dec 24, 2004·Molecular Biology of the Cell·Sandra E EncaladaBruce Bowerman
Aug 2, 2005·Nature Cell Biology·Birgit MeusserThomas Sommer
May 2, 2006·Journal of Structural Biology·Julien MouyssetThorsten Hoppe
May 17, 2006·Biochemical and Biophysical Research Communications·Seiji YamauchiTeru Ogura
May 22, 2007·Biochemical and Biophysical Research Communications·Yohei SasagawaTeru Ogura
Dec 1, 2007·WormBook : the Online Review of C. Elegans Biology·Sander van den Heuvel

❮ Previous
Next ❯

Citations

Jan 1, 1990·Life Sciences·D M Barten, R F O'Dea
May 11, 2011·Cell Research·Harish N Ramanathan, Yihong Ye
Feb 15, 2011·Nature Cell Biology·Kirsten KuhlbrodtThorsten Hoppe
Oct 25, 2011·Nature Cell Biology·Mayura MeerangKristijan Ramadan
Feb 3, 2012·Nature Cell Biology·Hemmo MeyerSebastian Bremer
Nov 29, 2011·Nature Structural & Molecular Biology·Klara AcsNico P Dantuma
Jan 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Cecilia BebeacuaPaul S Freemont
Aug 13, 2014·Proceedings of the National Academy of Sciences of the United States of America·Cheng-Gang ZouKe-Qin Zhang
Jul 31, 2013·Nature Chemical Biology·Paola MagnaghiAntonella Isacchi
Jun 5, 2015·Journal of Integrative Plant Biology·Qi-Na HuangJian-Li Wu
Oct 28, 2010·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yohei SasagawaTeru Ogura
Apr 4, 2015·Nucleus·Rachael BaileyAgnieszka Gambus
Jul 26, 2011·Biochimica Et Biophysica Acta·Kunitoshi YamanakaTeru Ogura
Oct 25, 2014·Science·Sara Priego MorenoAgnieszka Gambus
Jul 24, 2012·Trends in Cell Biology·Nico P Dantuma, Thorsten Hoppe
Apr 16, 2013·Biochimica Et Biophysica Acta·André FranzThorsten Hoppe
Dec 4, 2012·American Journal of Human Genetics·Lina Basel-VanagaiteGuntram Borck
Apr 30, 2013·Nature Cell Biology·Steven BerginkStefan Jentsch
May 21, 2016·Frontiers in Genetics·André FranzThorsten Hoppe
Oct 27, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Thaleia Papadopoulou, Holger Richly
Sep 25, 2017·International Journal of Molecular Sciences·Sentiljana GumeniIoannis P Trougakos
Jul 12, 2012·British Journal of Cancer·E MadanA A Mahdi
Oct 17, 2015·The EMBO Journal·Qian HaoZhaocai Zhou
Apr 3, 2019·Plant Molecular Biology·Lei ShiJian-Li Wu
Mar 11, 2020·Nature Communications·John FieldenKristijan Ramadan
Jul 22, 2019·DNA Repair·Julie RageulHyungjin Kim
Apr 14, 2011·Journal of Cell Science·Grzegorz DobryninHemmo Meyer
Oct 11, 2011·Molecular Cell·Harish N Ramanathan, Yihong Ye

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.