Cell Cycle Regulators and Lineage-Specific Therapeutic Targets for Cushing Disease

Frontiers in Endocrinology
Takako Araki, Ning-Ai Liu

Abstract

Cell cycle proteins are critical to pituitary development, but their contribution to lineage-specific tumorigenesis has not been well-elucidated. Emerging evidence from in vitro human tumor analysis and transgenic mouse models indicates that G1/S-related cell cycle proteins, particularly cyclin E, p27, Rb, and E2F1, drive molecular mechanisms that underlie corticotroph-specific differentiation and development of Cushing disease. The aim of this review is to summarize the literature and discuss the complex role of cell cycle regulation in Cushing disease, with a focus on identifying potential targets for therapeutic intervention in patients with these tumors.

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Citations

Nov 16, 2019·Journal of Clinical Medicine·Hiroshi Nishioka, Shozo Yamada
May 15, 2021·Frontiers in Endocrinology·José Miguel Hinojosa-AmayaDaniel Cuevas-Ramos

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Methods Mentioned

BETA
ubiquitination
transgenic

Clinical Trials Mentioned

NCT02160730

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