Cell cycle regulators in the control of metabolism.

Cell Cycle
Emilie BlanchetLluis Fajas

Abstract

We recently showed that the CDK4-pRB-E2F1 cell cycle regulators directly regulate the expression of Kir6.2, which is a key component of the K(ATP) channel involved in the regulation of glucose-induced insulin secretion. There is enough evidence to indicate that the CDK4-pRB-E2F1 regulatory pathway is involved in general glucose homeostasis, and metabolism. In this article we discuss which are the metabolic implications of these findings.

Citations

Feb 26, 2010·Cell Division·Lluis FajasJean-Sébastien Annicotte
May 26, 2012·PloS One·Aurélie DocquierVincent Cavaillès
Aug 11, 2010·Mitochondrion·Claudia BaltzerChristian Frei
Mar 13, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yuxia ZhangLi Wang
Jul 13, 2013·Current Biology : CB·David S Fay
Jan 13, 2015·Free Radical Biology & Medicine·Cuihong JinJian Jian Li
Jun 21, 2016·International Journal of Molecular Sciences·Ming-Ming TsaiKwang-Huei Lin
Jul 12, 2011·Physiological Reviews·Marcos Malumbres
May 11, 2018·Cell Death & Disease·Florian RouaudStéphane Rocchi

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