PMID: 18196965Jan 17, 2008Paper

Cell cycle switch to endocycle: the nucleolus lends a hand

Cell Cycle
David M J Martindill, Paul R Riley

Abstract

The bHLH transcription factor Hand1 is essential for placentation and cardiac morphogenesis but how its developmental activity is regulated is largely unknown. We recently showed that Hand1 is sequestered in the nucleoli of rodent trophoblast stem (TS) cells by the I-mfa domain-containing protein HICp40 and that this is associated with their proliferation and continuing self-renewal. However when these cells commit to differentiate into trophoblast giant (TG) cells, Hand1 is phosphorylated by the polo-like kinase Plk4 (Sak) and released into the nucleus to activate downstream target genes. This event underlies the release of Hand1 from the nucleolus and represents the 'molecular switch' that promotes mitotic cell cycle exit and the onset of endoreduplication. In this brief discussion we examine the wider implications of these findings and address some of the unanswered questions that remain.

Citations

Nov 4, 2009·Genes & Development·Hyun O LeeRobert J Duronio
Apr 21, 2009·The International Journal of Developmental Biology·Ralston M Barnes, Anthony B Firulli
Sep 19, 2009·Molecular BioSystems·Adrien Fauré, Denis Thieffry
Mar 18, 2009·The Journal of Cell Biology·Thoru Pederson, Robert Y L Tsai
Feb 21, 2009·EMBO Reports·Edward Emmott, Julian A Hiscox
Apr 19, 2012·Experimental Dermatology·Christophe ChapardMarcel Huber
Jul 8, 2015·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Candace Elaine RapchakMichael Crawford
Oct 26, 2010·Genomics, Proteomics & Bioinformatics·Amrutlal K PatelSuresh K Tikoo
Sep 17, 2009·Mechanisms of Development·Ahmed H K El-HashashSusan J Kimber
Oct 25, 2013·Development·Asako Sakaue-SawanoAtsushi Miyawaki

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