Cell cycling through Cdc25A: transducer of cytokine proliferative signals.

Cell Cycle
Christina KittipatarinAnnette R Khaled

Abstract

A balance between survival and proliferative signals maintains a constant number of T lymphocytes that populate the mammalian immune system, a process termed "homeostasis". Central to this process is the availability of a stromal cell product--the cytokine interleukin-7 (IL-7). We recently showed that IL-7, in addition to protecting cells from apoptosis, drives the cell cycling of lymphocytes through regulation of the stability of the phosphatase, Cdc25A, a key activator of cyclin-dependent kinases (cdks). IL-7 achieves this by controlling the activity of p38 MAP kinase (MAPK), which can phosphorylate Cdc25A, triggering its degradation. Sustained expression of Cdc25A had diverse effects: it promoted cell cycling, even in presence of cell cycle inhibitors such p27Kip1, and prevented cell shrinkage in response to cytokine deprivation. Herein we show a role for Cdc25A as a transducer of cytokine-driven proliferation and discuss novel implications for cell growth from the perspective of the requirements for maintenance of lymphocyte homeostasis.

Citations

Jan 22, 2010·Cancer Immunology, Immunotherapy : CII·Chang-Xuan YouPaul L Hermonat
May 4, 2010·Immunology Letters·Christina KittipatarinAnnette R Khaled
Dec 1, 2006·Mechanisms of Ageing and Development·Peter J Stambrook
Sep 5, 2007·Cytokine·Christina Kittipatarin, Annette R Khaled
Oct 4, 2012·Cell Cycle·Jennifer L Gryp, Gustavo J Gutierrez
Oct 4, 2012·Cell Cycle·Nikolaos PatsoukisVassiliki A Boussiotis
May 8, 2007·Biochimica Et Biophysica Acta·Ana Cuenda, Simon Rousseau
Mar 21, 2009·Journal of Immunological Methods·Christina Kittipatarin, Annette R Khaled
Aug 28, 2007·Journal of Dental Research·J F SchindlerW G Smith
Dec 16, 2017·Journal of Cellular Physiology·Wan-Jing CenJian-Wei Jiang

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