Cell death and reproductive regression in female Schistosoma mansoni.

PLoS Neglected Tropical Diseases
Sarah E GalantiEdward J Pearce

Abstract

The vitellarium is a highly proliferative organ, producing cells which are incorporated along with a fertilized ovum into the schistosome egg. Vitellarial growth fails to occur in virgin female schistosomes in single sex (female-only) infections, and involution of this tissue, which is accompanied by physical shrinkage of the entire worm, occurs when mature females sexually regress upon removal from their male partners. We have found that upon removal from their hosts into tissue culture, female parasites regress whether they are mated or not, but that cessation of egg production and a decline in expression of the vitelline gene p14 is delayed by mating. We used BrdU labeling to investigate whether there was a loss of proliferation in the vittelarium that might account for regression and found that the proliferation rate declined equally in paired and singled females once placed into culture. However, TUNEL staining and Caspase 3 activity measurements indicate that the loss of vitrellarial cellularity associated with regression is associated with profound apoptotic vitelline cell death, which is not apparent in the vitellaria of paired females immediately ex vivo, and which develops in vitro regardless of whether males are pres...Continue Reading

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Citations

Apr 9, 2015·Cellular Microbiology·Edward J Pearce, Stanley Ching-Cheng Huang
May 23, 2015·Future Medicinal Chemistry·Erinna F Lee, Walter Douglas Fairlie
Jan 8, 2014·Trends in Parasitology·Erinna F LeeW Douglas Fairlie
Aug 8, 2014·Frontiers in Genetics·Marion MorelColette Dissous
Nov 21, 2012·PLoS Neglected Tropical Diseases·Alexis A CogswellDavid L Williams
Nov 8, 2012·PLoS Pathogens·Stanley Ching-Cheng HuangEdward J Pearce
Dec 10, 2016·Chemistry & Biodiversity·Moara H G MartinsAntônio E M Crotti
Oct 20, 2018·Chemistry & Biodiversity·Renato L T ParreiraMárcio L Andrade E Silva
Jan 4, 2020·Parasitology Research·Yuanyuan XiaMiao Liu
Jul 7, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Wen-Jun ChengHong Jiang
Jan 18, 2013·PLoS Neglected Tropical Diseases·Paulu S R de SaramAnthony J Walker
Nov 23, 2016·PloS One·Daniela de Paula AguiarLizandra Guidi Magalhães
Mar 14, 2021·International Journal for Parasitology·Mudassar N MughalSimone Haeberlein
Jan 21, 2020·Molecular and Biochemical Parasitology·Danielle E SkinnerPaul J Brindley

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Datasets Mentioned

BETA
256576819

Methods Mentioned

BETA
dissecting
PCR

Software Mentioned

AxioVision
Openlab
IVision

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