PMID: 9176665May 1, 1997Paper

Cell death during tooth eruption in the rat: surrounding tissues of the crown

Anatomy and Embryology
H KanekoM Shimono

Abstract

We investigated the occurrence of apoptosis and other types of cell death around the crown during tooth eruption of the rat upper molar. The TdT-mediated-dUTP-biotin nick end labeling (TUNEL) method and transmission electron microscopy (TEM) were employed. Apoptosis was detected by both TUNEL and TEM in part of the reduced enamel epithelium and connective tissue in the resorbing bony crypt of the pre-erupted tooth. In TEM, a large number of cells showed condensed chromatin and membrane-bound small bodies (apoptotic bodies). Macrophages that phagocytosed apoptotic bodies could be detected. Based upon the distance between bone surface and these apoptotic cells, and the characteristics of their organelles, we suggested that the apoptotic cells might be osteocytes, bone-lining cells (osteoblasts), and macrophages. We surmised that the osteoclasts had also died. Cells which contained autophagic vacuoles and autophagosomes, and others whose cytoplasm had dissolved, were also frequently observed. No progressive cell death was found in the oral epithelium or the fibrous connective tissue over the crown. These results suggest that apoptosis gives rise to some cell death during tooth eruption, but that other types of cell death also occu...Continue Reading

Citations

Jan 7, 2000·Cell Biology International·T MeyerU Joos
Dec 14, 2011·Histochemistry and Cell Biology·Eizo NakagawaHan-Sung Jung
Nov 6, 2012·Journal of Molecular Histology·Su-Jin ParkJoo-Cheol Park
Sep 26, 2009·Anatomical Science International·Mitsuko MoriguchiTakaaki Yanagisawa
Mar 12, 2004·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Emiko TanakaMikihiko Kogo
May 5, 2006·Journal of Periodontology·Jaana WillbergMarketta Hormia
Jan 18, 2012·Journal of Periodontology·Marja T PöllänenVeli-Jukka Uitto
Jun 9, 2009·Journal of Biomechanics·T PopowicsS Herring
Apr 19, 2003·International Endodontic Journal·P G SatchellD E Witherspoon
Nov 22, 2005·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·P J EmansR Kuijer
Feb 24, 1999·Journal of Dental Research·I Kjaer, A Bagheri
Sep 6, 2001·Cell Death and Differentiation·W Bursch
Mar 6, 2015·Developmental Psychobiology·Michele R BrumleyHillary E Swann
May 15, 2002·Journal of Periodontal Research·R MabuchiM Shimono
Jul 6, 2021·Frontiers in Cell and Developmental Biology·John AbramyanMarcela Buchtová

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