PMID: 11921058Mar 29, 2002Paper

Cell death in experimental intracerebral hemorrhage: the "black hole" model of hemorrhagic damage

Annals of Neurology
Robert A FelbergJaroslaw Aronowski

Abstract

Intracerebral hemorrhage (ICH) has a poor prognosis that may be the consequence of the hematoma's effect on adjacent and remote brain regions. Little is known about the mechanism, location, and severity of such effects. In this study, rats subjected to intracerebral blood injection were examined at 100 days. Stereology (neuronal count and density) and volume measures in the perihematoma rim, the adjacent and overlying brain, and the substantia nigra pars reticulata (SNr) were compared with contralateral brain regions at 100 days and the perihemorrhage region at 24 hours and 7 days. In addition, cytochrome c release was investigated at 24 hours, 3 days, and 7 days. At 100 days, post-ICH rats showed no difference in neuronal density in the perihemorrhagic scar region or regions of the striatum immediately surrounding and distal to the perihemorrhage scar. The cell density index in the ipsilateral field was 16.2 +/- 3.8 versus the contralateral control field of 15.6 +/- 3.2 (not significant). Volume measurements of the ipsilateral striatum revealed a 20% decrease that was compensated by an increase in ipsilateral ventricular size. The area of the initial ICH as measured by magnetic resonance imaging correlated with the degree of a...Continue Reading

References

Jul 1, 1990·Trends in Neurosciences·A M Graybiel
Nov 1, 1990·Stroke; a Journal of Cerebral Circulation·T O Cheng
Oct 1, 1996·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·H K WolfI Blümcke
Jan 1, 1997·Stroke; a Journal of Cerebral Circulation·T BrottJ Khoury
Sep 23, 1998·The Journal of Cell Biology·S J NeameK L Philpott
Nov 5, 1999·Stroke; a Journal of Cerebral Circulation·S L HickenbottomJ Aronowski
Mar 4, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K MatsushitaE H Lo
Mar 15, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·I M JouY Yamano
May 11, 2001·The New England Journal of Medicine·A I QureshiD F Hanley
Sep 14, 2001·The Journal of Biological Chemistry·A ChengM P Mattson
Sep 1, 1996·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·C SillsJ Grotta

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Citations

Sep 15, 2004·Cell and Tissue Research·A K Stark, B Pakkenberg
Dec 7, 2007·Neurocritical Care·Michael Lucas JamesDaniel T Laskowitz
Feb 17, 2009·Journal of Neurotrauma·Crystal L MacLellanFrederick Colbourne
Mar 17, 2009·Stroke; a Journal of Cerebral Circulation·Masanobu OkauchiGuohua Xi
Apr 30, 2011·Stroke; a Journal of Cerebral Circulation·Jaroslaw Aronowski, Xiurong Zhao
Dec 9, 2008·Neurological Research·Jimin WuYa Hua
Feb 19, 2013·Journal of Neuroinflammation·Huang FangQing-Wu Yang
May 15, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xiurong ZhaoJaroslaw Aronowski
Mar 3, 2006·Journal of Neurosurgery·Ya HuaGuohua Xi
Apr 23, 2005·Neurological Research·Jaroslaw Aronowski, Christiana E Hall
Apr 4, 2014·Translational Stroke Research·Xiurong ZhaoJaroslaw Aronowski
Jul 19, 2008·Stroke; a Journal of Cerebral Circulation·Robert A KnightDonald M Seyfried
Jul 1, 2012·Translational Stroke Research·Fred Rincon, Stephan A Mayer
Feb 24, 2016·Brain Research Bulletin·Anil KumarVarun Gupta
Jul 26, 2011·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Ya-Xian WangLicheng Dai
Aug 30, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Crystal L MacLellanFrederick Colbourne
Jun 12, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Harriet E BarrattS Thomas Carmichael
Jul 17, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S Thomas CarmichaelNeil A Martin
Nov 8, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yangdong HeGuohua Xi
Oct 14, 2008·Experimental Neurology·Jason K Wasserman, Lyanne C Schlichter
Jul 14, 2005·Journal of Neurochemistry·Jiping TangJohn H Zhang
Nov 1, 2008·The European Journal of Neuroscience·Jason K WassermanLyanne C Schlichter
Jul 11, 2008·Journal of Neuroscience Research·Elena TitovaJiping Tang
Oct 21, 2014·Journal of Neurochemistry·Xiurong ZhaoJaroslaw Aronowski
Mar 21, 2009·Neurological Research·Anatol ManaenkoJiping Tang
Oct 22, 2013·Progress in Neurobiology·Guohua XiRichard F Keep
Dec 3, 2013·Progress in Neurobiology·Yu ZhouQing-Wu Yang

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