PMID: 9004234Dec 1, 1996Paper

Cell death in the normal developing brain, and following ionizing radiation, methyl-azoxymethanol acetate, and hypoxia-ischaemia in the rat

Neuropathology and Applied Neurobiology
I Ferrer

Abstract

Naturally occurring (programmed) cell death in the developing brain has morphological characteristics of apoptosis and is associated with internucleosomal DNA fragmentation. Apoptosis also plays a role in cell death following hypoxia-ischaemia in the developing rat brain. Ionizing radiation-induced cell death in the brain of the young rat has morphological characteristics of apoptosis, is mediated by protein synthesis and is associated with internucleosomal DNA fragmentation. Methyl-azoxymethanol (MAM) acetate injection in the young rat produces apoptotic cell death in the external granule cell layer of the cerebellum. In addition, strong c-Jun immunore-activity is observed in apoptotic cells during normal development and following experimentally induced cell death. Moreover, c-Jun mRNA induction and de novo c-Jun protein synthesis, together with activation of c-Jun/AP-1, as revealed with gel mobility shift assay, occurs in irradiated animals. Western blotting of total brain homogenates shows a c-Jun-immunoreactive band at p39, which corresponds to the molecular weight of c-Jun, in control rats. However, a thick c-Jun-immunoreactive band at about p62, accompanied by a decrease of the p39 band, occurs in irradiated and MAM-treat...Continue Reading

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Citations

Mar 5, 1999·Brain Research. Developmental Brain Research·C D AlbrightS H Zeisel
Feb 23, 2000·Neuroscience·I FerrerA M Planas
May 6, 1999·Brain Research Bulletin·O P Mishra, M Delivoria-Papadopoulos
Nov 3, 2005·International Journal of Radiation Biology·K NakayaG T Gobbel
Nov 4, 2000·Journal of Neurotrauma·J P MacManus, A M Buchan
Feb 12, 2005·Brain : a Journal of Neurology·J E BellN McIntosh
Feb 21, 2006·BJOG : an International Journal of Obstetrics and Gynaecology·J-C BecherB Wyatt
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Apr 3, 2012·Aging·Anna KovalchukOlga Kovalchuk
Nov 21, 2017·Journal of Alzheimer's Disease : JAD·Isidro Ferrer
May 20, 2000·Annals of the New York Academy of Sciences·M Delivoria-Papadopoulos, O P Mishra

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