Cell Death in the Origin and Treatment of Cancer

Molecular Cell
Andreas Strasser, David L Vaux

Abstract

Cell death, or, more specifically, cell suicide, is a process of fundamental importance to human health. Throughout our lives, over a million cells are produced every second. When organismal growth has stopped, to balance cell division, a similar number of cells must be removed. This is achieved by activation of molecular mechanisms that have evolved so that cells can destroy themselves. The first clues regarding the nature of one of these mechanisms came from studying genes associated with cancer, in particular the gene for BCL-2. Subsequent studies revealed that mutations or other defects that inhibit cell death allow cells to accumulate, prevent removal of cells with damaged DNA, and increase the resistance of malignant cells to chemotherapy. Knowledge of this mechanism has allowed development of drugs that kill cancer cells by directly activating the cell death machinery and by synergizing with conventional chemotherapy as well as targeted agents to achieve improved outcomes for cancer patients.

Citations

Sep 3, 2020·Nature Reviews. Molecular Cell Biology·Sammy BedouiAndreas Strasser
Jan 14, 2021·The EMBO Journal·Matthias Kist, Domagoj Vucic
Jan 20, 2021·Cancer Discovery·Elle Koren, Yaron Fuchs
Mar 11, 2021·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Yu TianDinglun Zhou
Apr 4, 2021·International Journal of Molecular Sciences·Julie BasGermain Gillet
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cinzia ForniSimone Beninati
Aug 13, 2021·Frontiers in Oncology·Alexia VereertbrugghenPablo Elías Morande
Sep 14, 2021·Biochemical Society Transactions·Erinna F Lee, W Douglas Fairlie
Sep 16, 2021·Cancer Metastasis Reviews·Iris Garrido-CanoPilar Eroles
Sep 19, 2021·Cell Death and Differentiation·Antonella MontinaroHenning Walczak
Sep 26, 2021·Cell Death Discovery·Bin LiuMeixiao Zhan
Dec 7, 2021·Natural Product Research·Paloma Silva de SouzaMichelle Frazão Muzitano
Dec 14, 2021·Frontiers in Cell and Developmental Biology·Chenqiang JiaGuanglei Zhuang

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