Cell death induced in a human glioblastoma cell line by p(65)+Be neutrons combined with cisplatin

Life Sciences
S BenzinaP Bischoff

Abstract

High linear energy transfer (LET) radiation have the ability to kill cancer cells resistant to conventional radiotherapy. On the other hand, protocols combining radiotherapy and chemotherapy are effective in eradicating certain inoperable cancers. In this study, we investigated the cytotoxicity of a co-treatment with fast neutrons and cisplatin in a human glioblastoma cell line, U-87. Cells cultured in vitro were irradiated with p(65)+Be neutrons in the presence of cisplatin. Cell survival and the induction of apoptosis and premature senescence were assessed at different time intervals thereafter, using a variety of methods. A marked reinforcement of the cytotoxicity was obtained when irradiation and cisplatin were associated. This reflected both an amplification of the apoptotic process and the induction of premature cell senescence. The efficiency of a combination between fast neutrons and cisplatin in inducing cell death in U-87 is more than additive. The present data concur with those we previously reported in a mouse lymphoma and suggest the potential utility of platinum compounds as adjuncts to future cancer therapy protocols using high-LET radiation.

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Citations

Apr 25, 2008·Canadian Journal of Physiology and Pharmacology·J M Akudugu, J P Slabbert
May 19, 2009·Canadian Journal of Physiology and Pharmacology·B B Mokaleng, J M Akudugu
Apr 14, 2009·International Journal of Radiation Oncology, Biology, Physics·Mira MaaloufClaire Rodriguez-Lafrasse
Feb 5, 2008·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·R M HermannO Pradier
Nov 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ana S GuerreiroAlexandre Arcaro

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