PMID: 6171549Jul 1, 1981Paper

Cell death: questions for histochemists concerning the causes of the various cytological changes

The Histochemical Journal
R A Lockshin, J Beaulaton

Abstract

The question of cell death is accessible to study by histochemists and many questions remain to be resolved. From a physiological point of view, the most important are the causal relationships. (1) At what phase in cell death is the synthesis of RNA disrupted and at what phase is the rate of degradation of RNA increased? (2) Does the disruption of synthesis result from a direct genetic command, or does it result indirectly from gradual deterioration of energy resources or optimal ionic conditions? (3) What properties, presumably of the substrate organelles, marks them for specific absorption into autophagic vacuoles? (4) What proteases and other hydrolases operate currently undetected in the cytoplasm? How are they controlled and regulated? (5) Why does the physiologically dying cell shrink and appear more dense? To what extent is a cell in this state able to regulate any metabolic parameter? The advent of newer, more sensitive and quantitative techniques, and greater attention to the controls and causes as opposed to the phenomena, should help to resolve these questions.

References

Jan 1, 1976·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·J M Bidlack, R A Lockshin
Oct 1, 1974·European Journal of Biochemistry·R Smith, V Turk
Apr 1, 1972·The Journal of Cell Biology·C Peracchia, B S Mittler
Oct 22, 1969·Biochemical and Biophysical Research Communications·G K Chua, W Bushuk
Sep 1, 1965·The Journal of Cell Biology·M Locke, J V Collins

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Citations

Jul 4, 2006·Histochemistry and Cell Biology·Carlos PenalozaZahra Zakeri
Jun 20, 2002·Journal of Immunological Methods·Zahra Zakeri, Richard A Lockshin
Nov 20, 2001·Molecular and Cellular Biology·K OnoJ Han
Nov 14, 2015·Cell Death and Differentiation·R A Lockshin
May 1, 1997·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S S Mpoke, J Wolfe
Jul 4, 2001·Nature Reviews. Molecular Cell Biology·R A Lockshin, Z Zakeri
Oct 1, 1992·Annals of Medicine·K Koli, J Keski-Oja
May 9, 2002·American Journal of Physiology. Cell Physiology·Lawrence M Schwartz, Robert L Ruff
Apr 1, 1993·The Journal of Investigative Dermatology·S B HoathS T Boyce

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