Cell-derived microparticles unveil their fibrinolytic and proteolytic function

Médecine sciences : M/S
Loïc Doeuvre, Eduardo Anglés-Cano

Abstract

Cell-derived microparticles (MP) are membrane microvesicles, 0.1-1 microm in size, shed by cells following activation or during apoptosis in a variety of pathological conditions. MPs released by blood cells or by vascular endothelial cells display molecular signatures that allow their identification and functional characterization. In addition, they provide tissue factor (TF) and a procoagulant phospholipid surface. Therefore, at present, the most strongly established applied research on MPs is their procoagulant activity as a determinant of thrombotic risk in various clinical conditions. Previous studies have indicated that MPs derived from malignant cells express matrix metalloproteinases, urokinase and its receptor (uPA/uPAR) that, in the presence of plasminogen, may act in concert to degrade extracellular matrix proteins. Recently, it was shown that MPs from TNFa-stimulated endothelial cells served as a surface for interaction with plasminogen and its conversion into plasmin by the uPA/uPAR system expressed at their surface. This capacity of MPs to promote plasmin generation confers them a new profibrinolytic and proteolytic function that may be of relevance in fibrinolysis, cell migration, angiogenesis, dissemination of ma...Continue Reading

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Citations

Feb 6, 2010·Médecine sciences : M/S·Fanny AngelotFrancine Garnache-Ottou
May 22, 2009·Journal of Neurochemistry·Loïc DoeuvreEduardo Anglés-Cano
Dec 29, 2009·Médecine sciences : M/S·Gérard SociéRégis Peffault de Latour
Oct 24, 2009·Médecine sciences : M/S·Eduardo Anglés-CanoSTROKAVENIR

Related Concepts

Blood Coagulation
Plasma Membrane
Cricetulus
Fibrinolysis
Cricetus
Ovarian Neoplasm
Phospholipids
Plasminogen
Chinese Hamster Ovary Cell
Apoptosis, Intrinsic Pathway

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