Cell differentiation within a yeast colony: metabolic and regulatory parallels with a tumor-affected organism

Molecular Cell
Michal CápZdena Palková

Abstract

Nutrient sensing and metabolic reprogramming are crucial for metazoan cell aging and tumor growth. Here, we identify metabolic and regulatory parallels between a layered, multicellular yeast colony and a tumor-affected organism. During development, a yeast colony stratifies into U and L cells occupying the upper and lower colony regions, respectively. U cells activate a unique metabolism controlled by the glutamine-induced TOR pathway, amino acid-sensing systems (SPS and Gcn4p) and signaling from mitochondria with lowered respiration. These systems jointly modulate U cell physiology, which adapts to nutrient limitations and utilize the nutrients released from L cells. Stress-resistant U cells share metabolic pathways and other similar characteristics with tumor cells, including the ability to proliferate. L cells behave similarly to stressed and starving cells, which activate degradative mechanisms to provide nutrients to U cells. Our data suggest a nutrient flow between both cell types, resembling the Cori cycle and glutamine-NH(4)(+) shuttle between tumor and healthy metazoan cells.

Associated Datasets

References

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Citations

Aug 29, 2012·Oxidative Medicine and Cellular Longevity·Libuše VáchováZdena Palková
Jul 26, 2012·Oxidative Medicine and Cellular Longevity·Michal CápZdena Palková
Feb 19, 2014·BMC Genomics·Vratislav ŠťovíčekZdena Palková
Dec 19, 2015·FEMS Yeast Research·Dhanabalan KanagavijayanMalathi Srinivasan
Jan 9, 2016·Current Genetics·Sarah PiccirilloSaul M Honigberg
Aug 15, 2013·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Sarah A Dick, Lynn A Megeney
May 21, 2014·Yeast·Didac Carmona-Gutierrez, Sabrina Büttner
Aug 24, 2013·Oxidative Medicine and Cellular Longevity·Libuše VáchováZdena Palková
Jan 16, 2015·Journal of Basic Microbiology·Fábio Faria-OliveiraCélia Ferreira
Apr 17, 2016·Seminars in Cell & Developmental Biology·Zdena Palková, Libuše Váchová
Apr 10, 2013·Current Opinion in Microbiology·Julie Bonhomme, Christophe d'Enfert
May 24, 2015·FEMS Yeast Research·Richard CalderoneAna Traven
Oct 15, 2014·Cell Reports·Joaquin F ChristiaensKevin J Verstrepen
Sep 20, 2012·Biochimica Et Biophysica Acta·Klaus Natter, Sepp D Kohlwein
May 24, 2014·Biophysical Journal·Clément VulinPascal Hersen
Jan 23, 2015·Molecular Biology of the Cell·Shamoon NaseemJames B Konopka
Oct 15, 2013·FEMS Yeast Research·Zdena PalkováLibuše Váchová
Dec 3, 2014·Nature Reviews. Genetics·Prisca LiberaliLucas Pelkmans
May 6, 2016·Journal of the Royal Society, Interface·Jennifer T PentzWilliam C Ratcliff
Nov 22, 2018·Thoracic Cancer·Ruifang ZhuZhiguang Duan
Jul 7, 2017·Yeast·Dominika M Wloch-SalamonBirgitte Regenberg
Jan 15, 2020·Proceedings of the National Academy of Sciences of the United States of America·Tien LeJan Tachezy
Jul 8, 2016·Aging·Zdena Palková, Libuše Váchová
Aug 31, 2018·FEMS Yeast Research·Nicoletta GuaragnellaSergio Giannattasio
Jun 4, 2020·International Journal of Molecular Sciences·Vítězslav PlocekZdena Palková
Jun 17, 2020·Proceedings of the National Academy of Sciences of the United States of America·Jana MaršíkováZdena Palková
May 17, 2018·Oxidative Medicine and Cellular Longevity·Derek WilkinsonZdena Palková
Jun 16, 2018·FEMS Yeast Research·Andreas ZimmermannDidac Carmona-Gutierrez
Sep 22, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Young-Yon KwonCheol-Koo Lee

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