PMID: 6989878Jun 1, 1980Paper

Cell-directed inhibition of polymorphonuclear leukocyte chemotaxis in a patient with mucocutaneous candidiasis

The Journal of Allergy and Clinical Immunology
K L CatesA T Davis

Abstract

A patient with mucocutaneous candidiasis and impaired polymorphonuclear leukocyte (PMN) chemotaxis is described. The patient's PMN chemotaxis was markedly decreased in the presence of autologous plasma but normal in control plasma. Cell-directed inhibitory activity was found in whole patient plasma as well as the 40% ammonium sulfate precipitate fraction of both the patient's and the control plasma. The inhibitor was heat stable, reversible, nondialyzable, eluted from DEAE cellulose with 0.005 M sodium phosphate buffer, and migrated with IgG on immunoelectrophoresis. The supernate from 40% ammonium sulfate-fractionated patient and control plasma contained a cell-directed enhancer of PMN chemotaxis that antagonized the cell-directed inhibitor activity. It is possible that the patient's chemotactic defect may be caused by imbalance between plasma factors that regulate chemotaxis.

References

Feb 1, 1977·The Journal of Pediatrics·A T DavisL M Pachman
May 1, 1973·The Journal of Clinical Investigation·J L Berenberg, P A Ward
Apr 1, 1973·Annals of Internal Medicine·R A ClarkC H Kirkpatrick
Apr 6, 1972·The New England Journal of Medicine·A N DeMeo, B R Andersen
Sep 29, 1966·The New England Journal of Medicine·D C ShannonK F Austen
Mar 24, 1955·Annals of the New York Academy of Sciences·J W REBUCK, J H CROWLEY

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Citations

Jan 1, 1989·Critical Reviews in Microbiology·J E Domer
Nov 1, 1995·Infection and Immunity·A Casadevall

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