PMID: 8602339Dec 1, 1995Paper

Cell envelope and cell wall immunization of Macaca fascicularis: effect on the progression of ligature-induced periodontitis

Oral Microbiology and Immunology
S C HoltJ L Ebersole

Abstract

The nonhuman primate, Macaca fascicularis, was used to study the role of immunization with selected members of the periodontopathic microbiota in the longitudinal progression of ligature-induced periodontitis. Animals were immunized with cell envelope antigens prepared from Porphyromonas gingivalis and Prevotella intermedia, and a mixture prepared from Fusobacterium nucleatum, Campylobacter rectus, and Actinomyces viscosus. Serum immunoglobulin G (IgG), IgM and IgA isotype antibodies increased significantly in all immunization groups and were specific for each of the immunogens. P. gingivalis and P. intermedia immunization resulted in a stabilization of the proportions of these species throughout most of the experiment. The high P. gingivalis antibody titer resulted in low P. gingivalis numbers being recovered. P. gingivalis immunization, while lowering recoverable viable P. gingivalis, resulted in significantly increased levels of Prevotella loescheii, Prevotella buccae, Bacteroides macacae and Prevotella melaninogenica compared with preligation and preimmunization levels. Actinobacillus actinomycetemcomitans, Capnocytophaga spp. and Eikenella spp. remained at preligation levels postimmunization. Campylobacter spp. increased s...Continue Reading

References

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Citations

Dec 10, 1998·Trends in Microbiology·C A GencoS Amar
Jun 1, 1994·Periodontology 2000·J L Ebersole, M A Taubman
Feb 19, 2011·Journal of Biomedicine & Biotechnology·Helieh S Oz, David A Puleo
Jun 25, 2010·Journal of Periodontology·Kunaal Dhingra, K L Vandana
Sep 1, 2005·Journal of Clinical Periodontology·G Rutger Persson
Jun 15, 2001·ILAR Journal·L R Sibal, K J Samson
Jul 5, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·E GemmellG J Seymour
Nov 24, 1998·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·P StashenkoR D'Souza
Aug 9, 2003·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Yen-Tung A Teng
Apr 27, 2004·Periodontology 2000·Erica Gemmell, Gregory J Seymour
Jan 12, 2001·Oral Microbiology and Immunology·M J SteffenJ L Ebersole
Oct 16, 1999·Periodontology 2000·S C HoltC A Genco
Nov 9, 2019·Clinical Oral Implants Research·Jingqing SunMeike Stiesch
Jul 30, 2019·FASEB BioAdvances·Subramanya N PandruvadaSarandeep S Huja

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