Cell envelope lipids in the pathophysiology of Mycobacterium tuberculosis

Future Microbiology
Parul SinghSangita Mukhopadhyay

Abstract

Mycobacterium tuberculosis is an intracellular bacterium that persists and replicates inside macrophages. The bacterium possesses an unusual lipid-rich cell envelope that provides a hydrophobic impermeable barrier against many environmental stressors and allows it to survive extremely hostile intracellular surroundings. Since the lipid-rich envelope is crucial for M. tuberculosis virulence, the components of the cell wall lipid biogenesis pathways constitute an attractive target for the development of vaccines and antimycobacterial chemotherapeutics. In this review, we provide a detailed description of the mycobacterial cell envelope lipid components and their contributions to the physiology and pathogenicity of mycobacteria. We also discussed the current status of the antimycobacterial drugs that target biosynthesis, export and regulation of cell envelope lipids.

References

Nov 27, 1992·Science·J TriasR Benz
Nov 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P E Reynolds
Nov 1, 1988·Infection and Immunity·L ZhangB R Andersen
Mar 15, 1988·European Journal of Biochemistry·M DafféG Lanéelle
Jul 1, 1988·Journal of General Microbiology·M Daffé, M A Laneelle
Mar 1, 1972·Bacteriological Reviews·M B Goren
Jul 14, 1995·Science·P A SielingP J Brennan
Jan 1, 1995·Annual Review of Biochemistry·P J Brennan, H Nikaido
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·Y YuanC E Barry
Nov 1, 1994·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·G S BesraP J Brennan
Oct 15, 1994·FEMS Microbiology Letters·V Jarlier, H Nikaido
Apr 1, 1996·Methods : a Companion to Methods in Enzymology·K Kobayashi, T Yoshida
Apr 7, 1998·Infection and Immunity·J D Ernst
Nov 26, 1998·Progress in Lipid Research·C E BarryY Yuan
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·I ApostolouG Gachelin
Oct 9, 1999·Journal of Bacteriology·B KartmannS Stengler
Nov 11, 1999·Clinical and Experimental Immunology·J FäldtM Ridell
Dec 10, 1999·Proceedings of the National Academy of Sciences of the United States of America·D M UnderhillA Aderem
Dec 28, 1999·Microbes and Infection·G R Strohmeier, M J Fenton
Mar 14, 2000·Immunity·J E GumperzS M Behar
Jul 19, 2000·Infection and Immunity·C Astarie-DequekerI Maridonneau-Parini

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Citations

Oct 12, 2018·Proceedings of the National Academy of Sciences of the United States of America·Violaine DuboisFabienne Girard-Misguich
Dec 17, 2019·Microbiological Research·Vivek VinodRaja Biswas
Mar 7, 2021·International Journal of Molecular Sciences·Marion PougetWilliam A Paxton
Jul 28, 2019·Microbiology Spectrum·Gabriel T MashabelaDigby F Warner
Jul 4, 2021·Current Opinion in Chemical Biology·Kyle J Biegas, Benjamin M Swarts
Jul 1, 2021·Chemical Reviews·Mira HolzheimerAdriaan J Minnaard
Oct 5, 2021·Lipids in Health and Disease·Daniel MekonnenAbraham Aseffa

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Methods Mentioned

BETA
deacylation
metabolomic profiling

Software Mentioned

ChemBioDraw

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