Cell Fate and Developmental Regulation Dynamics by Polycomb Proteins and 3D Genome Architecture

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
Vincent LoubiereGiacomo Cavalli

Abstract

Targeted transitions in chromatin states at thousands of genes are essential drivers of eukaryotic development. Therefore, understanding the in vivo dynamics of epigenetic regulators is crucial for deciphering the mechanisms underpinning cell fate decisions. This review illustrates how, in addition to its cell memory function, the Polycomb group of transcriptional regulators orchestrates temporal, cell and tissue-specific expression of master genes during development. These highly sophisticated developmental transitions are dependent on the context- and tissue-specific assembly of the different types of Polycomb Group (PcG) complexes, which regulates their targeting and/or activities on chromatin. Here, an overview is provided of how PcG complexes function at multiple scales to regulate transcription, local chromatin environment, and higher order structures that support normal differentiation and are perturbed in tumorigenesis.

References

Aug 9, 2002·Molecular and Cellular Biology·Stuart S LevineRobert E Kingston
Oct 11, 2002·Nature·Sooryanarayana VaramballyArul M Chinnaiyan
Apr 1, 2004·Molecular Cell·Gaetano I DellinoVincenzo Pirrotta
Jun 4, 2004·Molecular Cell·Liangjun WangRichard S Jones
Sep 24, 2004·Nature·Hengbin WangYi Zhang
May 21, 2005·The Journal of Biological Chemistry·Chongwoo A KimJames U Bowie
Nov 26, 2008·Molecular Cell·Raphael MargueronDanny Reinberg
Sep 15, 2009·Nature Genetics·Anne-Marie MartinezGiacomo Cavalli
Sep 22, 2009·Nature·Raphael MargueronSteven J Gamblin
Feb 4, 2010·Genes & Development·Gang LiDanny Reinberg
Feb 4, 2010·Genes & Development·Martin LeebAnton Wutz
May 4, 2010·Nature·Johanna C ScheuermannJürg Müller
Jul 28, 2010·Nucleic Acids Research·Maria A FerraiuoloJosée Dostie
Aug 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·João D PereiraFrederick J Livesey
Nov 5, 2010·The Journal of Biological Chemistry·Lilia KaustovCheryl H Arrowsmith
Dec 23, 2010·Future Oncology·Andrea Piunti, Diego Pasini
Jan 19, 2011·Cell·Frédéric BantigniesGiacomo Cavalli
Jul 29, 2011·Trends in Genetics : TIG·Frédéric Bantignies, Giacomo Cavalli
Oct 15, 2011·Science·Daan NoordermeerDenis Duboule
Jan 5, 2012·The Journal of Clinical Investigation·Floriana ForzatiAlfredo Fusco

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Citations

Jun 20, 2020·Journal of Experimental Botany·Ana Paula SantosSara Farrona
Jun 10, 2020·Nature Reviews. Cancer·Todd Waldman
Sep 9, 2020·Open Biology·Andrea Cerase, Gian Gaetano Tartaglia
Jan 12, 2021·Fly·Amel Chaouch, Paul Lasko
Jan 14, 2021·International Journal of Molecular Sciences·Junchul KimKyungpyo Park
Jan 6, 2021·Nature Communications·Sergey V UlianovSergey V Razin
Jul 7, 2020·Journal of Molecular Biology·Jin Joo KangNicole J Francis
Jun 4, 2021·BMC Biology·Maksim ErokhinDarya Chetverina
Jul 17, 2021·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Xiujuan Zhao, Xudong Wu
Aug 29, 2021·Viruses·Sara A DochnalAnna R Cliffe

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