Cell fate factor DACH1 represses YB-1-mediated oncogenic transcription and translation

Cancer Research
Kongming WuRichard G Pestell

Abstract

The epithelial-mesenchymal transition (EMT) enhances cellular invasiveness and confers tumor cells with cancer stem cell-like characteristics, through transcriptional and translational mechanisms. The mechanisms maintaining transcriptional and translational repression of EMT and cellular invasion are poorly understood. Herein, the cell fate determination factor Dachshund (DACH1), suppressed EMT via repression of cytoplasmic translational induction of Snail by inactivating the Y box-binding protein (YB-1). In the nucleus, DACH1 antagonized YB-1-mediated oncogenic transcriptional modules governing cell invasion. DACH1 blocked YB-1-induced mammary tumor growth and EMT in mice. In basal-like breast cancer, the reduced expression of DACH1 and increased YB-1 correlated with poor metastasis-free survival. The loss of DACH1 suppression of both cytoplasmic translational and nuclear transcriptional events governing EMT and tumor invasion may contribute to poor prognosis in basal-like forms of breast cancer, a relatively aggressive disease subtype.

References

Mar 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J Sommerville, M Ladomery
Dec 22, 1999·International Journal of Cancer. Journal International Du Cancer·K ShibaoH Itoh
Feb 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·M KurusuK Furukubo-Tokunaga
Apr 16, 2003·The Journal of Biological Chemistry·Karsten JurchottHans-Dieter Royer
Jun 20, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Kimitoshi KohnoMichihiko Kuwano
Nov 13, 2003·Molecular and Cellular Biology·Maofu FuRichard G Pestell
Dec 13, 2005·Nature Reviews. Cancer·Andreas G BaderPeter K Vogt
Mar 29, 2006·The Journal of Cell Biology·Jonathan M LeeErik W Thompson
Jul 1, 2006·Molecular and Cellular Biology·Toshiyuki SakamakiRichard Pestell
Sep 19, 2006·Molecular and Cellular Biology·Kongming WuRichard G Pestell
Dec 22, 2006·Molecular Biology of the Cell·Kongming WuRichard G Pestell
Jan 9, 2008·The Journal of Biological Chemistry·Zhiping LiRichard G Pestell
May 10, 2008·Proceedings of the National Academy of Sciences of the United States of America·Kongming WuRichard G Pestell
Mar 6, 2009·Nature Reviews. Cancer·Kornelia Polyak, Robert A Weinberg
Nov 10, 2009·Trends in Endocrinology and Metabolism : TEM·Vladimir M PopovRichard G Pestell
Jan 8, 2010·The Journal of Biological Chemistry·Xuanmao JiaoRichard G Pestell
Sep 1, 2008·Clinical and Translational Science·Jaime LindsayRichard G Pestell
Oct 13, 2010·The Journal of Biological Chemistry·Kongming WuRichard G Pestell
Oct 20, 2010·The Journal of Biological Chemistry·Jie ZhouRichard G Pestell
Dec 12, 2012·The Biochemical Journal·Annette LashamAntony W Braithwaite
Mar 16, 2013·Cancer Research·Ke ChenRichard G Pestell

❮ Previous
Next ❯

Citations

Jun 23, 2015·International Journal of Cancer. Journal International Du Cancer·Yu LiuKongming Wu
Oct 18, 2014·Journal of Hematology & Oncology·Qian ChuKongming Wu
Apr 17, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yong WangDan Yue
May 14, 2016·Nucleic Acids Research·Shawn M LyonsPavel Ivanov
Jul 15, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Tianyun PangXinrong Hu
May 31, 2019·Journal of Clinical Medicine·Josep BaulidaAntonio García de Herreros
May 1, 2016·The Journal of Biological Chemistry·Su-Hyeong KimShivendra V Singh
Oct 30, 2016·Oncotarget·Xing YangBaowei Jiao
Dec 22, 2017·Oncotarget·Kamila BledzkaKhalid Sossey-Alaoui
Aug 6, 2020·Molecular Carcinogenesis·Su-Hyeong KimShivendra V Singh
Sep 15, 2020·Journal of Biomolecular Structure & Dynamics·Mubashir HassanArif Malik
Dec 21, 2016·Breast Cancer Research : BCR·Natsue UehiroMasakazu Toi
Apr 21, 2019·Archives of Pharmacal Research·Kyung Hwa ChoHoi Young Lee
Apr 16, 2020·Biomolecules·Daria MordovkinaIrina Eliseeva
Feb 8, 2020·Journal of Experimental & Clinical Cancer Research : CR·Weihong NiuMing Zhou
Jun 19, 2020·Experimental Hematology & Oncology·Bing DongKongming Wu
Jul 1, 2017·Scientific Reports·Hanxiao XuKongming Wu
Sep 29, 2018·Head & Face Medicine·Jiarui ZhangMing Liu
Nov 4, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tao WangKe Chen
Mar 14, 2021·Cell Chemical Biology·Dhanir TailorSanjay V Malhotra
Mar 27, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Hailong RuanKe Chen
Jul 6, 2021·Cellular Signalling·Akram AlkrekshiKhalid Sossey-Alaoui

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Caveolins & Signal Transduction

Caveolins are small proteins with a hairpin loop conformation that are located in the plasma membrane of various cell types where they bind cholesterol and interact with receptors essential for several signal transduction pathways. Here is the latest research.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.