Cell fate in animal and human blastocysts and the determination of viability

Molecular Human Reproduction
Anna PiliszekBerenika Plusa

Abstract

Understanding the mechanisms underlying the first cell differentiation events in human preimplantation development is fundamental for defining the optimal conditions for IVF techniques and selecting the most viable embryos for further development. However, our comprehension of the very early events in development is still very limited. Moreover, our knowledge on early lineage specification comes primarily from studying the mouse model. It is important to recognize that although mammalian embryos share similar morphological landmarks, the timing and molecular control of developmental events may vary substantially between species.Mammalian blastocysts comprise three cell types that arise through two sequential rounds of binary cell fate decisions. During the first decision, cells located on the outside of the developing embryo form a precursor lineage for the embryonic part of the placenta: the trophectoderm and cells positioned inside the embryo become the inner cell mass (ICM). Subsequently, ICM cells differentiate into embryonic lineages that give rise to a variety of tissues in the developing fetus: either the epiblast or extraembryonic primitive endoderm. Successful formation of all three lineages is a prerequisite for impla...Continue Reading

References

Jun 1, 1977·The Journal of Experimental Zoology·S J Kelly
Jun 1, 1974·The British Journal of Dermatology·S S Bleehen
May 1, 1973·Developmental Biology·P G Calarco, C J Epstein
Jan 8, 1971·Nature·P C SteptoeJ M Purdy
Jul 1, 1969·The Journal of Experimental Zoology·P G Calarco, E H Brown
Jan 13, 1995·Science·B FeldmanM Goldfarb
Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·L LarueR Kemler
Aug 1, 1996·Current Opinion in Genetics & Development·S Guo, K J Kemphues
Jul 1, 1996·Biology of Reproduction·G NikasA H Handyside
May 27, 1997·Proceedings of the National Academy of Sciences of the United States of America·F A Brook, R L Gardner
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·E ArmanP Lonai
Jun 19, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R L Gardner
Oct 15, 1998·Molecular Reproduction and Development·D A RappoleeK Jacobson
Feb 13, 1999·Cell·R S Beddington, E J Robertson
Sep 2, 1999·Molecular Reproduction and Development·C M Pauken, D G Capco
Nov 25, 2000·Biology of Reproduction·N KirchhofH Niemann
Jan 7, 2003·Genes & Development·Ariel A AvilionRobin Lovell-Badge
Mar 1, 2003·Nature Genetics·Andras NagyRonald Plasterk
May 12, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kallayanee ChawengsaksophakFelix Beck
Jul 24, 2004·Seminars in Cell & Developmental Biology·Martin H Johnson, Josie M L McConnell
Jan 20, 2005·Journal of Cell Science·Berenika PlusaMagdalena Zernicka-Goetz
Jun 14, 2005·Developmental Biology·Stéphanie VinotSophie Louvet-Vallée
Nov 6, 2007·Development·Jens-Erik Dietrich, Takashi Hiiragi

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Citations

Jan 7, 2017·Journal of Cellular Biochemistry·Tao Zhong, Jun Zhou
Jan 10, 2018·Molecular Human Reproduction·Christopher L R Barratt
Aug 25, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Néstor Saiz, Anna-Katerina Hadjantonakis
Nov 3, 2020·Biomaterials Science·Chantelle SpiteriCiro Chiappini
Apr 13, 2021·Molecular Reproduction and Development·Mariagrazia PaonessaGiovanni Coticchio
May 1, 2021·Journal of Developmental Biology·Claudia SpringerKilian Simmet
Jul 3, 2021·Frontiers in Veterinary Science·Alba Pérez-GómezPriscila Ramos-Ibeas

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