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Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replication

Nature Structural & Molecular Biology

Feb 12, 2020

Daniel ArdeljanKathleen H Burns

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Abstract

LINE-1 retrotransposon overexpression is a hallmark of human cancers. We identified a colorectal cancer wherein a fast-growing tumor subclone downregulated LINE-1, prompting us to examine how LINE-1 expression affects cell growth. We find that nontransformed cells undergo a TP53-depende...read more

Mentioned in this Paper

Protein Expression
Retrotransposition
Growth Arrest
DNA Replication
LINE-1 Elements
Negative Regulation of Growth
TP53 gene
Finding
Protein Overexpression
DNA Replication Fork
108
Paper Details
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Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replication

Nature Structural & Molecular Biology

Feb 12, 2020

Daniel ArdeljanKathleen H Burns

PMID: 32042151

DOI: 10.1038/s41594-020-0372-1

Abstract

LINE-1 retrotransposon overexpression is a hallmark of human cancers. We identified a colorectal cancer wherein a fast-growing tumor subclone downregulated LINE-1, prompting us to examine how LINE-1 expression affects cell growth. We find that nontransformed cells undergo a TP53-depende...read more

Mentioned in this Paper

Protein Expression
Retrotransposition
Growth Arrest
DNA Replication
LINE-1 Elements
Negative Regulation of Growth
TP53 gene
Finding
Protein Overexpression
DNA Replication Fork
108

Feeds With Similar Papers

Transposable Elements

Transposable elements (tes) have profound effects on the structure, function and evolution of their host genomes.

Chromosomal Duplication

Chromosomal duplication is a result of extra genetic material within the area of the chromosome. The duplication may have no effect or may be expressed in the phenotype of that individual. Some duplications are thought to be of evolutionary selection. Discover the latest research on chromosomal duplication here.

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The Human Long Interspersed Element-1 Retrotransposon: An Emerging Biomarker of Neoplasia

Clinical ChemistryFebruary 12, 2017
Daniel ArdeljanKathleen H Burns
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