Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replication
LINE-1 retrotransposon overexpression is a hallmark of human cancers. We identified a colorectal cancer wherein a fast-growing tumor subclone downregulated LINE-1, prompting us to examine how LINE-1 expression affects cell growth. We find that nontransformed cells undergo a TP53-depende...read more
Mentioned in this Paper
Negative Regulation of Growth
DNA Replication Fork
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