PMID: 7540341Mar 1, 1995Paper

Cell-free and cell-associated viremia in pigs after oronasal infection with Aujeszky's disease virus

Veterinary Microbiology
H J Nawynck, M B Pensaert

Abstract

Nine pigs were examined for the presence of viremia during the first week after oronasal inoculation of 10(8.0) TCID50 Aujeszky's disease virus (ADV). Blood was taken at 1, 2, 3, 5 and 7 days post inoculation (PI) and the presence of cell-free ADV in plasma and of ADV-infected mononuclear cells was examined by titration and by cocultivation with permissive cells, respectively. The mononuclear cells of 6 of the 9 pigs, collected at 3 and 5 days PI were further separated into subpopulations of enriched monocytes and enriched lymphocytes. Both subpopulations were cocultivated. Nasal secretions were collected from 4 of the 9 pigs for the determination of virus titers and interferon concentrations. Both infected mononuclear cells and cell-free ADV were demonstrated in 5 pigs, infected mononuclear cells only were found in 2 pigs, and neither cell-associated or cell-free ADV were detected in 2 pigs. Two of the 7 viremic animals were positive on one single day, 3 on 2 days, 1 on 3 days and 1 on 4 days. The number of infected cells was approximately 5 times higher in monocytes than in lymphocytes. The highest virus titers were present in those nasal fluids with the lowest alpha-interferon concentration. A correlation between the titer o...Continue Reading

References

Jan 15, 1992·Veterinary Immunology and Immunopathology·S Chinsakchai, T W Molitor
Nov 1, 1989·Microbial Pathogenesis·J M PolJ T van Oirschot
Apr 1, 1985·Veterinary Immunology and Immunopathology·P S PaulW L Mengeling
Feb 1, 1986·Veterinary Immunology and Immunopathology·C Hammerberg, G G Schurig

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Citations

Jan 1, 1989·Comparative Immunology, Microbiology and Infectious Diseases·G Iglesias, J W Harkness
Oct 1, 1992·Comparative Immunology, Microbiology and Infectious Diseases·G IglesiasT Molitor
Jun 1, 1996·Journal of Virological Methods·A C ChangS C Lee
Apr 26, 1996·Journal of Virological Methods·T Y HoT J Chang
Nov 1, 1994·Virus Research·K L GlazenburgB P Peeters
Apr 1, 1996·Veterinary Microbiology·K IshikawaM Muramatsu
May 1, 1997·Veterinary Microbiology·A JönsT C Mettenleiter
Aug 26, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·E AlbinaB Charley
Mar 10, 1998·The Journal of Veterinary Medical Science·S KatayamaY Shimizu
Jul 18, 2018·Transboundary and Emerging Diseases·Yaowalak PanyasingRoongroje Thanawongnuwech
Oct 24, 2003·The Journal of General Virology·Herman W FavoreelMaurice B Pensaert
Feb 27, 2003·The Journal of General Virology·Gerlinde R Van de WalleMaurice B Pensaert
Apr 5, 2020·Pathogens·Kathlyn Laval, Lynn W Enquist

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