Cell-Free Circulating Methylated SEPT9 for Noninvasive Diagnosis and Monitoring of Colorectal Cancer

Disease Markers
Bo FuWei Liu

Abstract

Identification of early-stage tumor and monitoring therapeutic efficacy and recurrence or metastasis of colorectal cancer (CRC) are urgently warranted for improving the outcome of CRC patients and reducing the disease-related mortality. In this study, we evaluated the diagnostic value of cell-free circulating methylated SEPT9 (mSEPT9) for CRC and beyond CRC and examined the potentiality of mSEPT9 in assessing therapeutic efficacy and monitoring recurrence of CRC. Our results confirmed the favorable diagnostic value of plasma mSEPT9 for CRC, with a sensitivity of 61.22% (95% confidence interval (CI): 51.33%-70.27%) and specificity of 93.7% (95% CI: 91.09%-95.57%) using 2/3 algorithm. The positive rate of mSEPT9 in CRC was correlated with tumor size, histological grade, and general histological type (P < 0.05). Beyond CRC, gastric cancer patients also presented a high positive rate of plasma mSEPT9 (70%). The conversions between preoperative and postoperative plasma mSEPT9 reflected the therapeutic efficacy of curatively intended surgery for CRC patients. The persistent positivity of plasma mSEPT9 after surgery (within 7-14 days) was highly associated with impending recurrences or metastases (within one year), with a sensitivity ...Continue Reading

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Jan 10, 2020·Epigenomics·Manon DuforestelPierre-François Cartron
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Oct 1, 2021·Journal of Clinical Laboratory Analysis·Huiqin JiangWei Guo

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Methods Mentioned

BETA
PCR

Software Mentioned

SPSS18

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