Cell-free circulating tumour DNA as a liquid biopsy in breast cancer

Molecular Oncology
Leticia De Mattos-Arruda, Carlos Caldas

Abstract

Recent developments in massively parallel sequencing and digital genomic techniques support the clinical validity of cell-free circulating tumour DNA (ctDNA) as a 'liquid biopsy' in human cancer. In breast cancer, ctDNA detected in plasma can be used to non-invasively scan tumour genomes and quantify tumour burden. The applications for ctDNA in plasma include identifying actionable genomic alterations, monitoring treatment responses, unravelling therapeutic resistance, and potentially detecting disease progression before clinical and radiological confirmation. ctDNA may be used to characterise tumour heterogeneity and metastasis-specific mutations providing information to adapt the therapeutic management of patients. In this article, we review the current status of ctDNA as a 'liquid biopsy' in breast cancer.

References

Jan 29, 2010·Breast Cancer Research and Treatment·Ruth E BoardCaroline Dive
Apr 8, 2010·Science Translational Medicine·Rebecca J LearyVictor E Velculescu
Mar 15, 2011·Nature·Nicholas NavinMichael Wigler
Feb 22, 2012·Carcinogenesis·Arumugam NagalingamDipali Sharma
Mar 9, 2012·The New England Journal of Medicine·Marco GerlingerCharles Swanton
Mar 17, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michaela J HigginsBen H Park
May 23, 2012·Cell·Serena Nik-ZainalUNKNOWN Breast Cancer Working Group of the International Cancer Genome Consortium
Jun 1, 2012·Science Translational Medicine·Tim ForshewNitzan Rosenfeld
Jun 23, 2012·Nature·Philip J StephensMichael R Stratton
Jun 23, 2012·Molecular Cancer Therapeutics·Rodrigo DienstmannJosep Tabernero
Sep 25, 2012·Nature·UNKNOWN Cancer Genome Atlas Network
Dec 1, 2012·Science Translational Medicine·Rebecca J LearyVictor E Velculescu
Jan 16, 2013·International Journal of Cancer. Journal International Du Cancer·Ellen HeitzerMichael R Speicher
Feb 12, 2013·The EMBO Journal·Sarah-Jane DawsonCarlos Caldas
Mar 1, 2013·The New England Journal of Medicine·Samuel Aparicio, Carlos Caldas
Mar 15, 2013·The New England Journal of Medicine·Sarah-Jane DawsonNitzan Rosenfeld
May 1, 2013·Nature Reviews. Drug Discovery·Richard Simon, Sameek Roychowdhury
May 3, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Heidrun GevenslebenNicholas C Turner
May 29, 2013·Nature Reviews. Clinical Oncology·Leticia De Mattos-ArrudaJoan Seoane
Sep 21, 2013·Nature·Philippe L BedardLillian L Siu
Oct 19, 2013·The Oncologist·Leticia De Mattos-Arruda, Jordi Rodon
Nov 5, 2013·Nature Genetics·Dan R RobinsonArul M Chinnaiyan
Nov 5, 2013·Nature Genetics·Weiyi ToySarat Chandarlapaty
Jan 23, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Luis A Diaz, Alberto Bardelli
Feb 8, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Julia A BeaverBen Ho Park
Feb 21, 2014·Science Translational Medicine·Chetan BettegowdaLuis A Diaz
May 8, 2014·Cancer Discovery·Daniel A Haber, Victor E Velculescu
Jul 11, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L De Mattos-ArrudaJ S Reis-Filho
Aug 1, 2014·Science Translational Medicine·Carolin MüllerSabine Riethdorf
Aug 12, 2014·Breast Cancer Research : BCR·Maryam HeidaryMichael R Speicher
Aug 21, 2014·Cancer Discovery·James P SullivanDaniel A Haber
Sep 4, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F RothéM Ignatiadis
Oct 14, 2014·International Journal of Cancer. Journal International Du Cancer·Jordan MadicRonald Lebofsky
Nov 5, 2014·Cancer Discovery·Joan Seoane, Leticia De Mattos-Arruda

❮ Previous
Next ❯

Citations

Jul 22, 2016·Human Molecular Genetics·Devon M CayerNicholas J Schork
Aug 25, 2016·Virchows Archiv : an International Journal of Pathology·Paul Hofman, Helmut H Popper
Oct 25, 2016·Cancer Medicine·Jun-Long SongSheng-Rong Sun
Nov 1, 2016·Expert Review of Molecular Diagnostics·J F SwennenhuisL W M M Terstappen
Mar 10, 2018·Current Neurology and Neuroscience Reports·Maxime FontanillesAhmed Idbaih
Aug 8, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Amy Jo Chien, Hope S Rugo
Dec 23, 2017·Genome Medicine·Martin WidschwendterHarri Lempiäinen
Jan 11, 2019·Molecular Oncology·Simon Oberst
Nov 2, 2018·Genes, Chromosomes & Cancer·Evi Lianidou, Klaus Pantel
Oct 20, 2018·Therapeutic Drug Monitoring·M OellerichP D Walson
Mar 28, 2019·Genetic Testing and Molecular Biomarkers·Matthew ScarlottaAmy K Kim
Jan 29, 2020·Cancer Medicine·Maria PalmieriElisa Frullanti
Apr 14, 2018·World Journal of Clinical Oncology·Navid SobhaniBruna Scaggiante
Feb 28, 2018·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Manish KumarRosy Mondal
Mar 19, 2019·Therapeutic Drug Monitoring·Michael OellerichPhilip D Walson
Jan 24, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Santiago Ramón Y CajalJosep Castellví
Jul 31, 2020·International Journal of Molecular Sciences·Olorunseun O OgunwobiAkinfemi Akingboye
Oct 1, 2020·Cancers·Jiawei LiDong-Xu Liu
Apr 19, 2017·Proceedings of the National Academy of Sciences of the United States of America·Austin K MattoxNickolas Papadopoulos
Aug 29, 2018·Applied Biochemistry and Biotechnology·Neveen A HusseinMohamed A Ahmed
Apr 17, 2020·Cancers·Magali BoyerCatherine Alix-Panabières
Oct 22, 2020·Expert Review of Anticancer Therapy·Patrick NevenGuy Jerusalem
Jul 22, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mathieu ChicardGudrun Schleiermacher
Nov 29, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Giovanna RossiMassimo Cristofanilli
Dec 30, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sophia MastorakiEvi Lianidou
Feb 5, 2021·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Shi QuiHirotaka Iwase
Dec 20, 2020·Cancers·Alexandra MesquitaFernando Schmitt

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Cancer Sequencing

Several sequencing approaches are employed to understand and examine tumor development and progression. These include whole genome as well as RNA sequencing. Here is the latest research on cancer sequencing.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

© 2022 Meta ULC. All rights reserved