Cell-Free DNA in Oncology: Gearing up for Clinic

Annals of Laboratory Medicine
Bryan C Ulrich, Cloud P Paweletz

Abstract

In the past several years, interest in the clinical utility of cell-free DNA as a noninvasive cancer biomarker has grown rapidly. Success in the development of plasma genotyping assays and other liquid biopsy assays has widened the scope of cell-free DNA use in research and the clinic. Already approved by the US Food and Drug Administration in the narrow context of epidermal growth factor receptor-mutated non-small cell lung cancer, plasma genotyping assays are currently being investigated in a wide array of clinical settings and modalities. These include plasma genotyping as a tool for early diagnosis, the detection of minimal residual disease, and the evaluation of treatment response/progression. In this review, we assess the clinical landscape of plasma genotyping assays and propose strategies for their further expansion into routine clinical care.

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Citations

Mar 22, 2018·Genome Medicine·Anna Babayan, Klaus Pantel
Nov 23, 2018·Clinical Chemistry and Laboratory Medicine : CCLM·Natalie Reimers, Klaus Pantel
Aug 25, 2020·Annals of Laboratory Medicine·Yiming ZhongMarilyn M Li
Dec 6, 2019·Frontiers in Genetics·Warwick J LockeJason P Ross
Dec 29, 2020·Frontiers in Cell and Developmental Biology·Deepshi ThakralSangeeta Vashishtha
Aug 1, 2020·Transplantation·Edward John Filippone, John L Farber

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Methods Mentioned

BETA
genotyping
biopsy
biopsies
PCR
rebiopsy

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