Cell-free human immunodeficiency virus type 1 in breast milk

The Journal of Infectious Diseases
P LewisJ Overbaugh

Abstract

Breast-feeding may be an important route of human immunodeficiency virus type 1 (HIV-1) vertical transmission in settings where it is routinely practiced. To define the prevalence and quantity of HIV-1 in cell-free breast milk, samples from HIV-1-seropositive women were analyzed by quantitative competitive reverse transcription-polymerase chain reaction (QC-RT-PCR). HIV-1 RNA was detected in 29 (39%) of 75 specimens tested. Of these 29 specimens, 16 (55%) had levels that were near the detection limit of the assay (240 copies/mL), while 6 (21%) had >900 copies/mL. The maximum concentration of HIV-1 RNA detected was 8100 copies/mL. The prevalence of cell-free HIV-1 was higher in mature milk (47%) than in colostrum (27%, P = 0.1). Because mature milk is consumed in large quantities, these data suggest that cell-free HIV-1 in breast milk may contribute to vertical transmission of HIV-1.

References

Sep 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P Van de PerreF Dabis
Nov 9, 1991·BMJ : British Medical Journal·K M De CockR L Colebunders
Jan 1, 1995·AIDS Research and Human Retroviruses·L L O'NeilE A Hoover
Apr 1, 1994·AIDS Research and Human Retroviruses·T W BabaR M Ruprecht

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Citations

Mar 29, 2002·European Journal of Immunology·Jennifer CzarneskiSusan R Ross
Dec 2, 2000·Schizophrenia Research·E Fuller TorreyR H Yolken
Nov 25, 2003·Journal of Paediatrics and Child Health·B S EleyD W Beatty
Apr 1, 1999·The Journal of Infectious Diseases·J OverbaughJ Bwayo
Oct 23, 2004·The Journal of Infectious Diseases·Christine M RousseauJulie Overbaugh
Apr 12, 2003·AIDS Research and Human Retroviruses·Robin W Allison, Edward A Hoover
Oct 31, 2000·AIDS Patient Care and STDs·J C Georgeson, S M Filteau
Jul 13, 2006·AIDS Research and Human Retroviruses·William PhiriSuzanne M Filteau
Jan 15, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Grace John-StewartUNKNOWN Ghent IAS Working Group on HIV in Women Children
Aug 2, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jan WalterGrace M Aldrovandi
Apr 10, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Katherine SemrauGrace M Aldrovandi
Jul 21, 2012·Science Translational Medicine·Philippe Van de PerreEdouard Tuaillon
Dec 12, 2007·Antimicrobial Agents and Chemotherapy·Gadi BorkowJeffrey Gabbay
Jun 7, 2003·Journal of Clinical Microbiology·M K GhoshG M Aldrovandi
Jul 5, 2002·Journal of Virology·Steffanie SabbajGrace M Aldrovandi
Apr 24, 2001·Archives of Disease in Childhood·C A Michie, J Gilmour
Oct 22, 2005·The Journal of Clinical Investigation·Marloes A NaardingWilliam A Paxton
Nov 22, 2014·The Journal of Infectious Diseases·Caitlin Milligan, Julie Overbaugh
Oct 3, 1999·Lancet·D N Burns, L M Mofenson
Nov 17, 2010·Clinics in Perinatology·Marc BulterysAthena P Kourtis
Jun 14, 2003·Annals of Tropical Paediatrics·M O Ogundele, J B S Coulter
Jun 19, 2013·Immunological Reviews·Nicole H Tobin, Grace M Aldrovandi
Jun 19, 2013·Immunological Reviews·Lianna F WoodDonald L Sodora
Dec 14, 2005·Journal of Virological Methods·Pierre BecquartPhilippe Van de Perre
Sep 14, 2007·American Journal of Obstetrics and Gynecology·Athena P KourtisMary Glenn Fowler
Feb 3, 2007·Virology·Lynn M Herrmann-HoesingDonald P Knowles
Nov 6, 2004·Virology·Gavin J HendersonRonald Swanstrom
Apr 25, 2000·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·R D SembaJ D Chiphangwi

❮ Previous
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