Cell-free mitochondrial DNA copy number variation in head and neck squamous cell carcinoma: A study of non-invasive biomarker from Northeast India

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Manish KumarRosy Mondal

Abstract

Head and neck squamous cell carcinoma is the most commonly diagnosed cancer worldwide. The lifestyle, food habits, and customary practices manifest the Northeast Indian population toward higher susceptibility to develop head and neck squamous cell carcinoma. Here, we have investigated the association of smoke and smokeless tobacco, and alcohol with copy number variation of cell-free mitochondrial DNA and cell-free nuclear DNA in cases and controls. Cell-free DNA from plasma was isolated from 50 head and neck squamous cell carcinoma cases and 50 controls with informed written consent using QIAamp Circulating Nucleic Acid Kit. Real-time polymerase chain reaction was done for copy number variation in cell-free mitochondrial DNA and cell-free nuclear DNA. Receiver operating characteristic curve analysis was performed to evaluate the diagnostic application between the two study groups using clinicopathological parameters. The levels of cell-free nuclear DNA and cell-free mitochondrial DNA of cases in association with smoke and smokeless tobacco, alcohol with smoking (p < 0.05) were significantly higher (p < 0.01 and p < 0.001, respectively) than controls. Using receiver operating characteristic curve analysis between head and neck s...Continue Reading

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Citations

Apr 17, 2019·Cancer Biology & Therapy·Anatoli KustanovichAlbert Grinshpun
Jul 31, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hannah S RosaAfshan N Malik
Feb 28, 2018·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Manish KumarRosy Mondal
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Methods Mentioned

BETA
biopsies
biopsy
PCR

Software Mentioned

ABI StepOne Real - Time PCR

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