Cell-Free Mitochondrial DNA in the CSF: A Potential Prognostic Biomarker of Anti-NMDAR Encephalitis

Frontiers in Immunology
Yu PengHong-Hao Wang

Abstract

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune inflammatory brain disease that can develop a variety of neuropsychiatric presentations. However, the underlying nature of its inflammatory neuronal injury remains unclear. Mitochondrial DNA (mtDNA) is recently regarded as a damage-associated molecular pattern molecule (DAMP) that can initiate an inflammatory response. In the presenting study, we aimed to evaluate the levels of cell-free mtDNA in cerebrospinal fluid (CSF) of patients with anti-NMDAR encephalitis and to determine a potential role of cell-free mtDNA in the prognosis of anti-NMDAR encephalitis. A total of 33 patients with NMDAR encephalitis and 17 patients with other non-inflammatory disorders as controls were included in this study. The CSF levels of cell-free mtDNA were measured by quantitative polymerase chain reaction (qPCR). Cytokines including interleukin (IL)-6, IL-10, and tumor necrosis factor alpha (TNF-α) were measured by ELISA. The modified Rankin scale (mRS) score was evaluated for neurologic disabilities. Our data showed that the CSF levels of cell-free mtDNA and inflammation-associated cytokines were significantly higher in the patients with anti-NMDAR encephalitis compared with...Continue Reading

References

Aug 27, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Akiyuki UzawaSatoshi Kuwabara
Feb 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Norio ChiharaTakashi Yamamura
Feb 22, 2011·Trends in Immunology·Dmitri V KryskoPeter Vandenabeele
May 21, 2011·Nature Reviews. Immunology·A Phillip WestSankar Ghosh
Jul 30, 2011·EMBO Reports·Damien ArnoultStephen E Girardin
Apr 14, 2012·Brain Pathology·Jan BauerChristian G Bien
Jan 3, 2013·Annals of Neurology·Harald PrüssKlaus-Peter Wandinger
Dec 10, 2013·Annals of Neurology·Thaís ArmangueJosep Dalmau
May 2, 2014·Stroke; a Journal of Cerebral Circulation·Bastian ChengGötz Thomalla
Feb 26, 2016·Lancet Neurology·Francesc GrausJosep Dalmau
Oct 26, 2016·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Yu PengHonghao Wang
Apr 11, 2017·Nature Reviews. Immunology·A Phillip West, Gerald S Shadel

❮ Previous
Next ❯

Citations

Nov 18, 2019·Experimental Neurology·Yoshihiko NakamuraKazuhide Hayakawa
Mar 21, 2021·Seminars in Cell & Developmental Biology·Jyung Mean Son, Changhan Lee
Mar 23, 2021·Frontiers in Cell and Developmental Biology·Ji-Hyun Park, Kazuhide Hayakawa
Jun 8, 2021·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Sarah Sohyun ParkAna C Andreazza

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
ELISA

Software Mentioned

SPSS

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Anti-N-Methyl-D-Aspartate Receptor Encephalitis

Anti-N-Methyl-D-Aspartate (NMDA) receptor encephalitis is a form of of brain inflammation due to antibodies against NMDA receptors. Discover the latest research on anti-NMDA receptor encephalitis here.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.