Cell-free multi-layered collagen-based scaffolds demonstrate layer specific regeneration of functional osteochondral tissue in caprine joints

Biomaterials
Tanya J LevingstoneFergal J O'Brien

Abstract

Developing repair strategies for osteochondral tissue presents complex challenges due to its interfacial nature and complex zonal structure, consisting of subchondral bone, intermediate calcified cartilage and the superficial cartilage regions. In this study, the long term ability of a multi-layered biomimetic collagen-based scaffold to repair osteochondral defects is investigated in a large animal model: namely critical sized lateral trochlear ridge (TR) and medial femoral condyle (MC) defects in the caprine stifle joint. The study thus presents the first data in a clinically applicable large animal model. Scaffold fixation and early integration was demonstrated at 2 weeks post implantation. Macroscopic analysis demonstrated improved healing in the multi-layered scaffold group compared to empty defects and a market approved synthetic polymer osteochondral scaffold groups at 6 and 12 months post implantation. Radiological analysis demonstrated superior subchondral bone formation in both defect sites in the multi-layered scaffold group as early as 3 months, with complete regeneration of subchondral bone by 12 months. Histological analysis confirmed the formation of well-structured subchondral trabecular bone and hyaline-like car...Continue Reading

References

Aug 12, 1999·Zeitschrift für Rheumatologie·M SittingerG R Burmester
Sep 13, 2005·The Knee·Ian J P Henderson, David P La Valette
Mar 1, 2008·Osteoarthritis and Cartilage·E B Hunziker, A Stähli
Jun 10, 2008·Biomaterials·Anna TampieriIvan Martin
Sep 4, 2008·Journal of Biomedical Materials Research. Part a·Claire M TierneyFergal J O'Brien
Oct 11, 2008·Tissue Engineering. Part B, Reviews·Timothy M O'Shea, Xigeng Miao
Dec 23, 2008·Osteoarthritis and Cartilage·B J AhernT P Schaer
Jun 30, 2009·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Michael Robert CarmontTim Spalding
Feb 18, 2010·International Orthopaedics·Mazen FalahGershon Volpin
Sep 30, 2010·Journal of Biomedical Materials Research. Part a·Ander AbarrategiJosé Luis López-Lacomba
Aug 20, 2011·The Knee·Benedikt L ProffenMartha M Murray
Oct 22, 2011·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Aad A M DhollanderPeter C M Verdonk
Mar 27, 2012·Foot and Ankle Surgery : Official Journal of the European Society of Foot and Ankle Surgeons·Christopher J PearceJames D Calder
Jun 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jeannine M CoburnJennifer H Elisseeff
Apr 16, 2013·The American Journal of Sports Medicine·Joris E J BekkersDaniel B F Saris
Apr 17, 2013·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Paul HindleLeela C Biant
Jul 3, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Patrick OrthHenning Madry
Oct 3, 2013·Critical Reviews in Biotechnology·Jennifer K LeeKyriacos A Athanasiou
Jan 5, 2014·Clinical Orthopaedics and Related Research·Frank G LyonsFergal J O'Brien
Jan 15, 2014·Acta Biomaterialia·Tanya J LevingstoneJohn P Gleeson
Jan 1, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Irene Mencía CastañoFergal J O'Brien
Mar 25, 2015·Advanced Healthcare Materials·Amos MatsikoFergal J O'Brien
May 20, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Rosanne M RafteryFergal J O'Brien
Sep 29, 2015·Advanced Healthcare Materials·Elaine QuinlanAdolfo López-Noriega
Jan 3, 2016·Acta Biomaterialia·Tanya J LevingstoneFergal J O'Brien
Feb 26, 2016·Journal of Experimental Orthopaedics·Conor J MoranTanya J Levingstone
May 21, 2016·Journal of Tissue Engineering and Regenerative Medicine·J David StackFlorent David

❮ Previous
Next ❯

Citations

Sep 11, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Chin-San Wu
Oct 25, 2016·International Journal of Pharmaceutics·Sandra Camarero-Espinosa, Justin Cooper-White
Apr 8, 2017·Journal of Biomedical Materials Research. Part a·Vikrant RaiDevendra K Agrawal
Dec 16, 2017·Journal of Tissue Engineering and Regenerative Medicine·Sajedeh Khorshidi, Akbar Karkhaneh
May 21, 2016·Journal of Tissue Engineering and Regenerative Medicine·J David StackFlorent David
Aug 15, 2017·Advanced Healthcare Materials·Andrew C DalyDaniel J Kelly
Nov 9, 2017·Journal of Biomedical Materials Research. Part a·Drew ClearfieldMei Wei
Aug 24, 2018·Tissue Engineering. Part a·Drew S ClearfieldMei Wei
Jan 17, 2019·Tissue Engineering. Part B, Reviews·Mohsen SetayeshmehrMohammad T Joghataei
Feb 6, 2019·International Journal of Molecular Sciences·Friederike BotheSebastien Hagmann
Oct 11, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xue FengChangyou Gao
Dec 6, 2017·The Journal of Bone and Joint Surgery. American Volume·Matthew J Allen
Aug 15, 2020·Biochemical Society Transactions·Mark LemoineFergal J O'Brien
Jul 12, 2017·Journal of Tissue Engineering·Altug YucekulMahmut Nedim Doral
Feb 23, 2020·Biochemistry Research International·Xiangbo MengXinluan Wang
Jun 14, 2017·Pharmaceuticals·Bethanie I AyerstAnthony J Day
Jul 1, 2020·Advanced Healthcare Materials·Francesco SantarellaCathal J Kearney
Aug 28, 2020·Micromachines·Georgia KastaniaDmitry Volodkin
Feb 10, 2018·Regenerative Biomaterials·Zhurong TangXingdong Zhang
Sep 11, 2019·Biotechnology and Bioengineering·Javier NavarroJohn P Fisher
Nov 29, 2020·Journal of Materials Science. Materials in Medicine·Min ZhuZhongtang Liu
Dec 15, 2020·Tissue Engineering. Part B, Reviews·Anna TrengoveAndrea J O'Connor
Nov 17, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Francesco SantarellaCathal J Kearney
Jan 19, 2021·Advanced Functional Materials·Jeremy M Lowen, J Kent Leach
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Francisco R Almeida-GonzálezClaire M Brougham
Mar 10, 2021·Journal of Biomedical Materials Research. Part a·Fatemeh HejaziHamid Mirzadeh
Mar 20, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Austyn R MathesonTannin A Schmidt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.