Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1

Science
Y E ChinX Y Fu

Abstract

Signal transducers and activators of transcription (STAT) proteins can be conditionally activated in response to epidermal growth factor (EGF) and interferon (IFN)-gamma. STAT activation was correlated with cell growth inhibition in response to EGF and IFN-gamma. Activated STAT proteins specifically recognized the conserved STAT-responsive elements in the promoter of the gene encoding the cyclin-dependent kinase (CDK) inhibitor p21 WAF1/CIP1 and regulated the induction of p21 messenger RNA. IFN-gamma did not inhibit the growth of U3A cells, which are deficient in STAT1, but did inhibit the growth of U3A cells into which STAT1 alpha was reintroduced. Thus, STAT1 protein is essential for cell growth suppression in response to IFN-gamma. The STAT signaling pathway appears to negatively regulate the cell cycle by inducing CDK inhibitors in response to cytokines.

References

Jul 29, 1977·Science·A W Hamburger, S E Salmon
Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M J GutchN C Reich
Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D ResnitzkyA Kimchi
Aug 25, 1992·Proceedings of the National Academy of Sciences of the United States of America·X Y FuJ E Darnell
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·R McKendryG R Stark
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·X Y FuJ E Darnell
Dec 1, 1987·Cell Structure and Function·K KatohH Kondoh
Oct 19, 1995·Nature·J N Ihle
Apr 1, 1995·Molecular Biology of the Cell·J W HarperE Swindell
May 15, 1995·Genes & Development·C J Sherr, J M Roberts
Aug 1, 1994·Genes & Development·H ZhangD Beach
Nov 19, 1993·Cell·W S el-DeiryB Vogelstein
Dec 16, 1993·Nature·Y XiongD Beach

❮ Previous
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Citations

Mar 4, 2000·International Journal of Cancer. Journal International Du Cancer·A PanskyM H Heim
Oct 27, 1997·Journal of Cellular Physiology·A J WuB J Baum
May 29, 2000·Journal of Cellular Physiology·M OhtsuboN Shimizu
Feb 27, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·K Nakayama, K Nakayama
Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G S Crary, J H Albrecht
Feb 1, 2000·Biochemical and Biophysical Research Communications·T SasaguriJ Ogata
Feb 13, 2001·Biochemical and Biophysical Research Communications·J W ParkT K Kwon
Jan 25, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Miguel Angel Alejandre AlcazarJörg Dötsch
Sep 16, 2011·Cancer Immunology, Immunotherapy : CII·Cailin Moira WilkeWeiping Zou
Apr 20, 2010·Japanese Journal of Ophthalmology·Ungsoo Samuel KimJoon H Lee
Jul 31, 2013·Apoptosis : an International Journal on Programmed Cell Death·Ibrahim AlanaziDavid L Adelson
Dec 1, 2010·Journal of Ocular Biology, Diseases, and Informatics·Samuel Shao-Min ZhangColin J Barnstable
Apr 28, 2004·Cytokine & Growth Factor Reviews·Dhananjaya V Kalvakolanu
Jun 12, 2002·Biochemical and Biophysical Research Communications·Takayuki YamanakaTakefumi Doi
Apr 23, 2003·Biochemical and Biophysical Research Communications·Mari HikasaShunichi Shiozawa
Jun 4, 1999·Progress in Biophysics and Molecular Biology·K Shuai
Apr 18, 2003·Cancer Genetics and Cytogenetics·Flávia C C RodriguesEloiza H Tajara
Jul 17, 1999·Trends in Neurosciences·E CattaneoC De-Fraja
May 22, 1998·Trends in Genetics : TIG·P S Moore, Y Chang
Mar 5, 1999·Brain Research. Molecular Brain Research·D UbertiV Rotter
Jan 4, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·T YanoK Sugimachi
Mar 15, 2000·Molecular and Cellular Endocrinology·I P TouwM H Hermans
Jun 25, 1998·Current Opinion in Immunology·K D LiuM A Goldsmith
Apr 21, 1999·Current Opinion in Cell Biology·P O HackelA Ullrich
Oct 1, 1996·Current Opinion in Genetics & Development·S Watanabe, K i Arai

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