PMID: 8608088Jan 1, 1995Paper

Cell growth on insulin/RGDS-coimmobilized poly(methyl methacrylate) films

Journal of Biomaterials Science. Polymer Edition
J ZhengY Imanishi

Abstract

The tetrapeptide, Arg-Gly-Asp-Ser (RGDS), which corresponds to a core sequence of cell adhesion proteins, was coimmobilized with insulin on to surface-hydrolyzed poly(methyl methacrylate) film. Adhesion of STO mouse fibroblast cells was enhanced by the immobilization of RGDS, but not of insulin. On the other hand, growth of the cells was accelerated by the insulin immobilization, but not by the RGDS immobilization. Coimmobilization of insulin and RGDS did not affect cell adhesion but accelerated cell growth remarkably. This acceleration effect is considered to be attributable to a prolonged interaction of immobilized insulin and insulin receptor by adhesion enhancement, and to a postulated interaction between activated insulin receptor and integrin.

References

May 29, 1992·Journal of Medicinal Chemistry·P L BarkerM T Lipari
Mar 1, 1992·Journal of Biomedical Materials Research·A NicolD W Urry
May 1, 1991·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A Ben-Ze'ev
Jan 31, 1992·Biochemical and Biophysical Research Communications·R MizutaniY Arata
Nov 1, 1991·Journal of Biomedical Materials Research·Y ItoY Imanishi
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M KasugaC R Kahn
Aug 1, 1993·International Journal of Biological Macromolecules·S Q LiuY Imanishi
Jan 1, 1997·Journal of Molecular Evolution·Y TatenoT Gojobori
Jan 20, 1995·Biotechnology and Bioengineering·Y ItoY Imanishi

❮ Previous
Next ❯

Citations

Jan 20, 1995·Biotechnology and Bioengineering·Y ItoY Imanishi
Aug 1, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·V ChytryJ Jozefonvicz
Sep 2, 1998·Journal of Biomaterials Science. Polymer Edition·Y ItoY Imanishi
Jan 28, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·T HayakawaK Nemoto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.