Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis

Cell
Carla G SilvaLaurent Nguyen

Abstract

Interneurons navigate along multiple tangential paths to settle into appropriate cortical layers. They undergo a saltatory migration paced by intermittent nuclear jumps whose regulation relies on interplay between extracellular cues and genetic-encoded information. It remains unclear how cycles of pause and movement are coordinated at the molecular level. Post-translational modification of proteins contributes to cell migration regulation. The present study uncovers that carboxypeptidase 1, which promotes post-translational protein deglutamylation, controls the pausing of migrating cortical interneurons. Moreover, we demonstrate that pausing during migration attenuates movement simultaneity at the population level, thereby controlling the flow of interneurons invading the cortex. Interfering with the regulation of pausing not only affects the size of the cortical interneuron cohort but also impairs the generation of age-matched projection neurons of the upper layers.

Citations

May 24, 2018·International Journal of Molecular Sciences·Francesca LiCausi, Nathaniel W Hartman
Mar 16, 2019·Nature Reviews. Neuroscience·Carla G SilvaLaurent Nguyen
Apr 1, 2020·Frontiers in Cell and Developmental Biology·Naotaka Nakazawa, Mineko Kengaku
Nov 21, 2018·Development·Denis Jabaudon, Madeline Lancaster
Nov 5, 2019·F1000Research·Victor Borrell
Jan 21, 2021·Proceedings of the National Academy of Sciences of the United States of America·Maria Elena PeroFrancesca Bartolini
Nov 19, 2020·Trends in Neurosciences·Míriam Javier-TorrentLaurent Nguyen
Feb 16, 2021·Frontiers in Cell and Developmental Biology·Manuela D MitsogiannisEve Seuntjens
Jan 23, 2021·Neuroscience Letters·Satish BodakuntlaMaria M Magiera
Oct 19, 2020·Current Opinion in Neurobiology·Orly ReinerTamar Sapir
Oct 24, 2020·Current Opinion in Neurobiology·Fiona Francis, Silvia Cappello

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Datasets Mentioned

BETA
GSE104090
PXD006397

Methods Mentioned

BETA
acetylation
PCR
genotyping
ELISA
pull-down
fluorescence-activated cell sorting
dissection
FACS
Protein Assay
Assay

Software Mentioned

Cuffdiff
LifeAct
Mascot Distiller Tool
Decipher
KNIME
R
Tuxedo
ms
Ruby
Mascot

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