PMID: 6978184Mar 1, 1982Paper

Cell kinetics of lithium-induced granulopoiesis

Cell and Tissue Kinetics
V S Gallicchio, M G Chen

Abstract

Lithium has been shown to be an effective inducer of granulopoiesis. The mechanism of lithium action has been shown to influence CFU-s and CFU-c proliferation, increase colony-stimulating factor (CSF) production and reduce erythropoiesis. We report here evidence to show that lithium recruits CFU-c that are not normally in the cell cycle into active DNA synthesis, as measured by hydroxyurea and tritiated thymidine suicide techniques. Furthermore, lithium action is shown to be time-dependent, since the delay addition of lithium for 5 min to normal bone marrow removes the enhancement usually seen when lithium is given at time zero. The implications of these lithium-induced effects are described.

References

Jun 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·C Hori, T Oka
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Citations

Aug 1, 1993·International Journal of Immunopharmacology·V S GallicchioK F Tse
Feb 5, 1998·British Journal of Haematology·A BallinD Meytes
Jan 1, 1988·Immunopharmacology and Immunotoxicology·M P FuggettaA Giuliani
Feb 1, 1985·International Journal of Radiation Oncology, Biology, Physics·E LauretE Frindel
Dec 1, 1983·International Journal of Cell Cloning·V S GallicchioT D Watts
Jul 1, 1984·International Journal of Cell Cloning·J NinaneM Symann

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